Effects of laparoscopic sleeve gastrectomy on weight loss and metabolic improvement in subjects aged 65 years or older: a subanalysis of J-SMART study.

IF 1.2 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2024-10-13 eCollection Date: 2025-01-01 DOI:10.1007/s13340-024-00767-w

Yasuhiro Watanabe, Takashi Yamaguchi, Akira Sasaki, Takeshi Naitoh, Hisahiro Matsubara, Koutaro Yokote, Shinichi Okazumi, Satoshi Ugi, Hiroshi Yamamoto, Masayuki Ohta, Yasushi Ishigaki, Kazunori Kasama, Yosuke Seki, Motoyoshi Tsujino, Kohji Shirai, Yasuhiro Miyazaki, Takayuki Masaki, Daiji Nagayama, Ichiro Tatsuno, Atsuhito Saiki

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引用次数: 0

Abstract

Aim: To investigate the effect of weight loss and metabolic improvement after laparoscopic sleeve gastrectomy (LSG) in older adults aged 65 years or over compared with younger adults in a retrospective analysis.

Methods: The J-SMART study database of 322 Japanese individuals with body mass index (BMI) ≥32 kg/m² who underwent LSG between 2011 and 2014 at 10 centers accredited by the Japanese Society for Treatment of Obesity were analyzed. The subjects were classified into two groups: ≥65 age group (range, 65-76 years; n = 25) and <65 age group (range, 22-64 years; n = 297). Clinical parameters were compared between the groups.

Results: Baseline data for the ≥65 vs. <65 age groups were: median age 67 years vs. 45 years; weight 92.7 kg vs. 114.4 kg; BMI 40.0 kg/m² vs. 41.9 kg/m²; and HbA1c 6.8% vs. 6.5%. The ≥65 age group had significantly lower preoperative weight, BMI, estimated glomerular filtration rate, and ABCD score, but higher visceral fat area and prevalence of diabetes, hypertension, and obstructive sleep apnea (OSAS). Weight was significantly reduced in both groups throughout 5 years post-LSG, though total weight loss at 2 years was lower in the ≥65 age group (28.0%) than in the <65 group (30.0%). Remission rates of diabetes, hypertension, OSAS, and joint disorders 2 years after LSG showed no significant differences, except for dyslipidemia.

Conclusion: LSG may be an efficacious option for improving obesity-related health problems in older adults. However, postoperative safety and complications were not evaluated in this study and further research is needed.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-024-00767-w.

查看原文本刊更多论文

腹腔镜袖胃切除术对65岁及以上受试者体重减轻和代谢改善的影响：J-SMART研究的一项亚分析

目的：回顾性分析65岁及以上老年人腹腔镜袖胃切除术（LSG）后体重减轻和代谢改善的效果，并与年轻人进行比较。方法：采用J-SMART研究数据库，对2011 - 2014年间在日本肥胖治疗学会认可的10个中心接受LSG治疗的322名体重指数(BMI)≥32 kg/m2的日本患者进行分析。受试者分为两组：≥65岁组(范围：65 ~ 76岁；n = 25)和结果：基线数据≥65 vs. 2 vs. 41.9 kg/m2；HbA1c分别为6.8%和6.5%。≥65岁年龄组术前体重、BMI、肾小球滤过率和ABCD评分明显降低，但内脏脂肪面积和糖尿病、高血压和阻塞性睡眠呼吸暂停（OSAS）患病率较高。在LSG后的5年中，两组的体重都显著下降，尽管≥65岁年龄组的2年总体重下降（28.0%）低于结论：LSG可能是改善老年人肥胖相关健康问题的有效选择。然而，本研究未对术后安全性和并发症进行评估，需要进一步研究。补充信息：在线版本包含补充资料，提供地址：10.1007/s13340-024-00767-w。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.