Impact of tumor position displacement during end-exhalation breath-hold condition on tumor dose in lung stereotactic body radiation therapy using volumetric modulated arc therapy

IF 2.7 3区 医学 Q3 ONCOLOGY
Tatsuya Kamima , Shunsuke Moriya , Takeji Sakae , Hikaru Miyauchi , Yasushi Ito , Kenji Tokumasu , Yasuo Yoshioka
{"title":"Impact of tumor position displacement during end-exhalation breath-hold condition on tumor dose in lung stereotactic body radiation therapy using volumetric modulated arc therapy","authors":"Tatsuya Kamima ,&nbsp;Shunsuke Moriya ,&nbsp;Takeji Sakae ,&nbsp;Hikaru Miyauchi ,&nbsp;Yasushi Ito ,&nbsp;Kenji Tokumasu ,&nbsp;Yasuo Yoshioka","doi":"10.1016/j.ctro.2025.100916","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose</h3><div>In lung stereotactic body radiation therapy (SBRT) using a breath-holding technique, displacement of tumor during breath-holding is rarely considered. This study used four-dimensional (4D) dose calculation with cine computed tomography (CT) to evaluate the impact of unexpected tumor position displacement during breath-holding on the target dose of lung volumetric modulated arc therapy (VMAT)-SBRT.</div></div><div><h3>Materials and methods</h3><div>This study included 20 cases for which tumor position displacement during end-exhalation breath-holding (range: 0.5–12.6 mm) was evaluated on cine CT. VMAT-SBRT plans (3D dose) were generated using treatment planning CT images (reference CT) acquired during end-exhalation breath-hold. For each plan, the 4D dose was calculated using deformable image registration of the cine CT images and was accumulated onto the reference CT. Dose metrics and the mean biologically effective dose at <span><math><mrow><mi>α</mi><mo>/</mo><mi>β</mi></mrow></math></span> = 10 (BED<sub>10</sub>) for the gross tumor volume (GTV) were compared between 3D and 4D doses.</div></div><div><h3>Results</h3><div>In the 17 cases where the tumor was within the planning target volume (PTV) during breath-holding, the difference between the 3D and 4D doses was within 3 % for each dose metric. However, in 3 cases where the tumor position during breath-holding included displacement outside the PTV, both the D<sub>98%</sub> and mean BED<sub>10</sub> of the GTV were reduced by 6.9–20.0 % and 2.1–13.8 %, respectively, in 4D doses compared to 3D doses.</div></div><div><h3>Conclusion</h3><div>Our study showed that tumor position displacements during breath-holding may lead to substantial tumor dose reduction.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"51 ","pages":"Article 100916"},"PeriodicalIF":2.7000,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772987/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Radiation Oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405630825000060","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and purpose

In lung stereotactic body radiation therapy (SBRT) using a breath-holding technique, displacement of tumor during breath-holding is rarely considered. This study used four-dimensional (4D) dose calculation with cine computed tomography (CT) to evaluate the impact of unexpected tumor position displacement during breath-holding on the target dose of lung volumetric modulated arc therapy (VMAT)-SBRT.

Materials and methods

This study included 20 cases for which tumor position displacement during end-exhalation breath-holding (range: 0.5–12.6 mm) was evaluated on cine CT. VMAT-SBRT plans (3D dose) were generated using treatment planning CT images (reference CT) acquired during end-exhalation breath-hold. For each plan, the 4D dose was calculated using deformable image registration of the cine CT images and was accumulated onto the reference CT. Dose metrics and the mean biologically effective dose at α/β = 10 (BED10) for the gross tumor volume (GTV) were compared between 3D and 4D doses.

Results

In the 17 cases where the tumor was within the planning target volume (PTV) during breath-holding, the difference between the 3D and 4D doses was within 3 % for each dose metric. However, in 3 cases where the tumor position during breath-holding included displacement outside the PTV, both the D98% and mean BED10 of the GTV were reduced by 6.9–20.0 % and 2.1–13.8 %, respectively, in 4D doses compared to 3D doses.

Conclusion

Our study showed that tumor position displacements during breath-holding may lead to substantial tumor dose reduction.
求助全文
约1分钟内获得全文 求助全文
来源期刊
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.30
自引率
3.20%
发文量
114
审稿时长
40 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信