Association between estimated glomerular filtration rate, urinary albuminuria-creatinine ratio, and stroke prevalence in patients with chronic kidney disease.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-27 DOI:10.1080/0886022X.2025.2452219

Jianfeng Xiang, Mengli Tong, Dongrong Yu, Yinfeng Chen

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引用次数: 0

Abstract

Background: With the global increase in chronic diseases, chronic kidney disease (CKD) and stroke have become major public health concerns. This study aims to investigate the relationship between estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), and the incidence of stroke in a CKD population.

Methods: This cross-sectional study analyzed the relationship between eGFR, UACR, and prevalence of self-reported stroke in 6,037 participants using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. Multivariate logistic regression analysis was used to evaluate the association of eGFR, UACR with the incidence of stroke, and smoothing curve fitting was applied to explore the linear relationship between eGFR and stroke. To further explore the effect of eGFR on stroke risk, we performed subgroup analyses of demographic factors.

Results: After adjusting for confounding factors, eGFR was found to be significantly negatively associated with stroke risk. Compared with participants with an eGFR ≥ 90 mL/min/1.73 m², the risk of stroke was increased in those with an eGFR of 60-90 (OR = 1.78; 95% CI = 1.18-2.69), 30-60 (OR = 2.26; 95% CI = 1.49-3.44), and <30 mL/min/1.73 m² (OR = 3.14; 95% CI = 1.74-5.65). In the unadjusted model, patients with UACR of 30-300 mg/g had a slightly lower risk of stroke than those with UACR < 30 mg/g (OR = 0.70, 95% CI = 0.57-0.86); however, this association was not seen after adjusting for potential confounders.

Conclusions: This study identified a negative linear correlation between eGFR and stroke in CKD patients.

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慢性肾病患者肾小球滤过率、尿蛋白尿-肌酐比值与卒中患病率之间的关系

背景：随着全球慢性疾病的增加，慢性肾脏疾病（CKD）和中风已成为主要的公共卫生问题。本研究旨在探讨肾小球滤过率（eGFR）、尿白蛋白与肌酐比值（UACR）与CKD人群卒中发生率之间的关系。方法：本横断面研究使用2007年至2018年国家健康与营养检查调查（NHANES）的数据，分析了6037名参与者的eGFR、UACR和自述卒中患病率之间的关系。采用多因素logistic回归分析评价eGFR、UACR与脑卒中发病率的相关性，采用平滑曲线拟合探讨eGFR与脑卒中的线性关系。为了进一步探讨eGFR对卒中风险的影响，我们对人口统计学因素进行了亚组分析。结果：在调整混杂因素后，发现eGFR与卒中风险呈显著负相关。与eGFR≥90 mL/min/1.73 m2的受试者相比，eGFR为60-90的受试者卒中风险增加(OR = 1.78；95% ci = 1.18-2.69), 30-60 (or = 2.26；95% CI = 1.49-3.44), 2 (OR = 3.14；95% ci = 1.74-5.65)。在未调整的模型中，UACR为30-300 mg/g的患者发生卒中的风险略低于UACR < 30 mg/g的患者（OR = 0.70, 95% CI = 0.57-0.86）；然而，在调整了潜在的混杂因素后，没有发现这种关联。结论：本研究确定了eGFR与CKD患者卒中之间的负线性相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.