Similar Survival Between Non-Western Immigrant Patients and Danish-Born Patients with Lymphoma: A Danish Population-Based Study.

IF 3.4 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI:10.2147/CLEP.S484797

Mikkel Runason Simonsen, Eva Futtrup Maksten, Lasse Hjort Jakobsen, Marianne Tang Severinsen, Eldad J Dann, Henrik Frederiksen, Carsten Utoft Niemann, Judit Mészáros Jørgensen, Michael Roost Clausen, Jørn Starklint, Søren Paaske Johnsen, Tarec Christoffer El-Galaly, Joachim Baech

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引用次数: 0

Abstract

Purpose: This nationwide Danish cohort study compared overall survival (OS) between non-Western immigrant patients and Danish-born patients with lymphoma in Denmark. Furthermore, differences in clinical and socioeconomic variables were compared, and mediators of OS differences were explored to explain possible outcome differences.

Patients and methods: The study included a total of 540 non-Western patients and 16,294 Danish-born patients diagnosed with lymphoma in the period 2000-2020. Inverse probability weighting and mediation analysis using a natural effects Cox model were used to investigate the causal relationship between immigration status and OS.

Results: Indirect effects mediated through differences in performance status and income indicated a trend towards inferior OS for non-Western immigrant patients with HRs of 1.06 (0.99-1.14) and 1.06 (0.99-1.14). However, no total causal effect of immigration status on OS was observed overall (HR: 0.94 [0.79-1.12]) and within subtype-specific analyses, except for classical Hodgkin lymphoma.

Conclusion: No significant differences in OS between non-Western immigrant patients and Danish-born patients were discovered.

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非西方移民患者和丹麦出生的淋巴瘤患者生存率相似：一项基于丹麦人群的研究。

目的：这项全国性的丹麦队列研究比较了丹麦非西方移民患者和丹麦出生的淋巴瘤患者的总生存率（OS）。此外，我们比较了临床和社会经济变量的差异，并探讨了OS差异的中介因素，以解释可能的结果差异。患者和方法：该研究包括2000-2020年期间诊断为淋巴瘤的540名非西方患者和16,294名丹麦出生的患者。采用逆概率加权和自然效应Cox模型进行中介分析，探讨移民身份与OS之间的因果关系。结果：非西方移民患者的HRs分别为1.06（0.99-1.14）和1.06(0.99-1.14)，通过工作状态和收入差异介导的间接效应表明其OS有较差的趋势。然而，除了经典霍奇金淋巴瘤外，总体上没有观察到移民身份对OS的总因果影响（HR: 0.94[0.79-1.12]）和亚型特异性分析。结论：非西方移民患者与丹麦出生患者的OS无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology Medicine-Epidemiology

CiteScore

6.30

自引率

5.10%

发文量

169

审稿时长

16 weeks

期刊介绍： Clinical Epidemiology is an international, peer reviewed, open access journal. Clinical Epidemiology focuses on the application of epidemiological principles and questions relating to patients and clinical care in terms of prevention, diagnosis, prognosis, and treatment. Clinical Epidemiology welcomes papers covering these topics in form of original research and systematic reviews. Clinical Epidemiology has a special interest in international electronic medical patient records and other routine health care data, especially as applied to safety of medical interventions, clinical utility of diagnostic procedures, understanding short- and long-term clinical course of diseases, clinical epidemiological and biostatistical methods, and systematic reviews. When considering submission of a paper utilizing publicly-available data, authors should ensure that such studies add significantly to the body of knowledge and that they use appropriate validated methods for identifying health outcomes. The journal has launched special series describing existing data sources for clinical epidemiology, international health care systems and validation studies of algorithms based on databases and registries.