Hyperthyroidism in a Twin Pregnancy With a Hydatidiform Mole and a Coexisting Live Fetus: Management Dilemmas.

JCEM case reports Pub Date : 2025-01-24 eCollection Date: 2025-02-01 DOI:10.1210/jcemcr/luaf013
Samantha Jacobson, Jonathan-Raphaël Stetco, Richard Brown, Natasha Garfield
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Abstract

Hyperthyroidism in twin pregnancies involving a hydatidiform mole and a coexisting live fetus is a rare condition requiring careful management. We present a 34-year-old pregnant woman at 12 weeks' gestation with severe nausea, vomiting, and mild vaginal bleeding. A transvaginal ultrasound revealed a dichorionic diamniotic twin pregnancy with 1 normal fetus and 1 hydatidiform mole, leading to hyperthyroidism from elevated β human chorionic gonadotropin levels. Conservative management without antithyroid medications, combined with regular monitoring, allowed the pregnancy to continue to term, resulting in the delivery of a healthy baby at 39 weeks. Postpartum management required treatment of retained products of conception. This case highlights the complexities in the management of complications for both mother and fetus.

双胎妊娠合并甲状腺功能亢进症是一种罕见的情况,涉及水胎记和同时存在的活胎,需要谨慎处理。我们接诊了一名 34 岁的孕妇,她在妊娠 12 周时出现严重恶心、呕吐和轻微阴道出血。经阴道超声波检查发现是二绒毛膜双胎妊娠,其中有一个正常胎儿和一个水滴形痣,β 绒毛膜促性腺激素水平升高导致甲状腺功能亢进。在没有服用抗甲状腺药物的情况下,通过保守治疗和定期监测,妊娠得以顺利进行,并在妊娠 39 周时产下一名健康婴儿。产后管理需要对滞留的受孕产物进行治疗。该病例凸显了母亲和胎儿并发症治疗的复杂性。
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