Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children

EJHaem Pub Date : 2024-12-18 DOI:10.1002/jha2.1054

Hitomi Yonesu, Satoru Hamada, Hideki Sakiyama, Shinobu Kiyuna, Tokiko Oshiro, Nobuyuki Hyakuna, Koichi Nakanishi

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Abstract

Introduction

The nutritional risk index (NRI), calculated using serum albumin levels and body weight ratio is a known prognostic factor in adult hematopoietic cell transplantation (HCT). However, its usefulness in pediatric HCT settings remains unclear.

Methods

In a retrospective study, we examined pre-transplant NRI impact on outcomes in 82 pediatric patients undergoing allogeneic HCT.

Results

The 2-year non-relapse mortality (NRM) rate was 7.94% (95% confidence interval [CI], 3.05%–19.8%) and 30.8% (95% CI, 16.7%–52.2%) in the high and low NRI groups, respectively (p = 0.0037).

Conclusion

We found that poor nutritional status prior to pediatric HCT led to a worse prognosis, including increased NRM.

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简介营养风险指数（NRI）是利用血清白蛋白水平和体重比值计算得出的，是成人造血细胞移植（HCT）的一个已知预后因素。然而，该指数在儿科造血干细胞移植中的作用仍不明确：在一项回顾性研究中，我们考察了82名接受异基因造血干细胞移植的儿科患者移植前NRI对预后的影响：结果：高 NRI 组和低 NRI 组的 2 年非复发死亡率（NRM）分别为 7.94%（95% 置信区间 [CI]，3.05%-19.8%）和 30.8%（95% CI，16.7%-52.2%）（P = 0.0037）：我们发现，小儿 HCT 前营养状况不良会导致预后较差，包括 NRM 增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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EJHaem

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