Genome-Wide Insights into Internalizing Symptoms in Admixed Latin American Children.

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY

Genes Pub Date : 2025-01-08 DOI:10.3390/genes16010063

Gabriela de Sales Guerreiro Britto, Alberto O Moreira, Edson Henrique Bispo Amaral, Daniel Evangelista Santos, Raquel B São Pedro, Thaís M M Barreto, Caroline Alves Feitosa, Darci Neves Dos Santos, Eduardo Tarazona-Santos, Maurício Lima Barreto, Camila Alexandrina Viana de Figueiredo, Ryan Dos Santos Costa, Ana Lúcia Brunialti Godard, Pablo Rafael Silveira Oliveira

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引用次数: 0

Abstract

Background/objectives: Internalizing disorders, including depression and anxiety, are major contributors to the global burden of disease. While the genetic architecture of these disorders in adults has been extensively studied, their early-life genetic mechanisms remain underexplored, especially in non-European populations. This study investigated the genetic mechanisms underlying internalizing symptoms in a cohort of Latin American children.

Methods: This study included 1244 Brazilian children whose legal guardians completed the Child Behavior Checklist (CBCL) questionnaire. Genotyping was performed using the Illumina HumanOmni 2.5-8v1 BeadChip.

Results: The genome-wide association analysis revealed a significant association of rs7196970 (p = 4.5 × 10^-8, OR = 0.61), in the ABCC1 gene, with internalizing symptoms. Functional annotation highlighted variants in epigenetically active regulatory regions, with multiple variants linked to differential expression of ABCC1 across several human tissues. Pathway enrichment analysis identified 42 significant pathways, with notable involvement in neurobiological processes such as glutamatergic, GABAergic, and dopaminergic synapses.

Conclusions: This study identifies ABCC1 variants as novel genetic factors potentially associated with early-life internalizing symptoms. These results may contribute to future research on targeted interventions for childhood internalizing conditions.

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从基因组全局洞察拉丁美洲混血儿童的内化症状。

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来源期刊

Genes GENETICS & HEREDITY-

CiteScore

5.20

自引率

5.70%

发文量

1975

审稿时长

22.94 days

期刊介绍： Genes (ISSN 2073-4425) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to genes, genetics and genomics. It publishes reviews, research articles, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.