Polychlorinated biphenyls induced toxicities upon cell lines and stem cells: a review.

IF 3.2 3区环境科学与生态学 Q3 ENGINEERING, ENVIRONMENTAL

Environmental Geochemistry and Health Pub Date : 2025-01-24 DOI:10.1007/s10653-025-02362-7

Muhammad Zaffar Hashmi, Anaela Shoukat, Siwatt Pongpiachan, Yasar N Kavil, Saeed Saad Alelyani, Mohammed M Alkasbi, Mohamed Hussien, Md Toushik Ahmed Niloy

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引用次数: 0

Abstract

Polychlorinated biphenyls (PCBs) are persistent organic pollutants emitted during e-waste activities. Upon release into the environment, PCBs can pose harmful effects to the humans and environment. The present review focused on the effects of PCBs on cell proliferation, apoptosis, functional and developmental toxicity and potential possible molecular mechanisms upon cells and stem cells. The review also highlights the effects of low- and high-chlorinated, and dioxin and non-dioxin PCBs. The review suggested that high chlorinated and dioxin like PCBs at higher concentrations posed more toxic effects to cells and stem cells. PCBs at higher levels induced hepatotoxicity, carcinogenicity, reproductive toxicity, neurotoxicity and lung cell toxicity. PCBs triggered reactive oxygen species which actives mitogen activated pathways, nuclear factor and cytochrome pathway for cell proliferation and apoptosis. Further, review highlights PCBs induced toxicity in stem cells with the focus on developmental and functional toxicity. The review could be useful to understand the PCBs toxicities and mechanisms and will guide to policy makers to design policies for e-waste pollutant.

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来源期刊

Environmental Geochemistry and Health 环境科学-工程：环境

CiteScore

8.00

自引率

4.80%

发文量

279

审稿时长

4.2 months

期刊介绍： Environmental Geochemistry and Health publishes original research papers and review papers across the broad field of environmental geochemistry. Environmental geochemistry and health establishes and explains links between the natural or disturbed chemical composition of the earth’s surface and the health of plants, animals and people. Beneficial elements regulate or promote enzymatic and hormonal activity whereas other elements may be toxic. Bedrock geochemistry controls the composition of soil and hence that of water and vegetation. Environmental issues, such as pollution, arising from the extraction and use of mineral resources, are discussed. The effects of contaminants introduced into the earth’s geochemical systems are examined. Geochemical surveys of soil, water and plants show how major and trace elements are distributed geographically. Associated epidemiological studies reveal the possibility of causal links between the natural or disturbed geochemical environment and disease. Experimental research illuminates the nature or consequences of natural or disturbed geochemical processes. The journal particularly welcomes novel research linking environmental geochemistry and health issues on such topics as: heavy metals (including mercury), persistent organic pollutants (POPs), and mixed chemicals emitted through human activities, such as uncontrolled recycling of electronic-waste; waste recycling; surface-atmospheric interaction processes (natural and anthropogenic emissions, vertical transport, deposition, and physical-chemical interaction) of gases and aerosols; phytoremediation/restoration of contaminated sites; food contamination and safety; environmental effects of medicines; effects and toxicity of mixed pollutants; speciation of heavy metals/metalloids; effects of mining; disturbed geochemistry from human behavior, natural or man-made hazards; particle and nanoparticle toxicology; risk and the vulnerability of populations, etc.