Lu Gao, Hao Wu, Jia Feng, Yu Liu, Ruina Wang, Lan Yan, Quanzhen Lv, Yuanying Jiang
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引用次数: 0
Abstract
Invasive fungal infections have become an increasingly serious threat to global human health, underscoring the urgent need for the development of new antifungal drugs. In this study, we found a natural polyphenolic compound 1,2,3,4,6-O-pentagalloyl-glucose (PGG), which is present in various plants and herbs. PGG showed broad-spectrum antifungal activities, enhancing the efficacy of fluconazole. Furthermore, PGG could protect mice against gastrointestinal and systemic infection with Candida albicans. Our mechanistic studies revealed that PGG exerts its antifungal effects partially by binding to the CaEno1 protein to inhibit its activity. As a crucial therapeutic target, Eno1 has been reported to be closely associated with cancer, hypertension, and infectious diseases. Our findings indicated that PGG, a new Eno1 inhibitor, is a potential candidate for further antifungal development.
侵袭性真菌感染已成为全球人类健康日益严重的威胁,迫切需要开发新的抗真菌药物。在本研究中,我们发现了一种天然的多酚类化合物1,2,3,4,6- o -五五酰葡萄糖(PGG),它存在于各种植物和草药中。PGG表现出广谱的抗真菌活性,增强了氟康唑的药效。此外,PGG还能保护小鼠免受胃肠道和全身白色念珠菌感染。我们的机制研究表明,PGG部分通过与CaEno1蛋白结合抑制其活性来发挥其抗真菌作用。作为一个重要的治疗靶点,Eno1已被报道与癌症、高血压和感染性疾病密切相关。我们的研究结果表明,PGG是一种新的en1抑制剂,是进一步抗真菌开发的潜在候选者。
期刊介绍:
Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.