The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging

IF 10.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Pub Date : 2025-01-24 DOI:10.1093/brain/awaf026

Lucas E Sainburg, Dario J Englot, Victoria L Morgan

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引用次数: 0

Abstract

Resective epilepsy surgery can be an effective treatment for patients with medication-resistant focal epilepsy. Epilepsy resection consists of the surgical removal of an epileptic focus to stop seizure generation and disrupt the epileptic network. However, even focal surgical resections for epilepsy lead to widespread brain network changes. Understanding the impact of epilepsy surgery on the brain is crucial to improve surgical outcomes for patients. Here we provide a summary of studies imaging the postsurgical effects of epilepsy resection on the brain. We focus on MRI and PET studies of temporal lobe and pediatric epilepsy, reflecting the current literature. We discuss three potential mechanisms for surgery-induced brain changes: damage and degeneration, recovery, and reorganization. We additionally review the postsurgical brain correlates of surgical outcomes as well as the potential to predict the impact of surgery on an individual patient’s brain. A comprehensive characterization of the impact of surgery on the brain and precise methods to predict these brain network changes could lead to more personalized surgeries that improve seizure outcomes and reduce neuropsychological deficits after surgery.

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来源期刊

Brain 医学-临床神经学

CiteScore

20.30

自引率

4.10%

发文量

458

审稿时长

3-6 weeks

期刊介绍： Brain, a journal focused on clinical neurology and translational neuroscience, has been publishing landmark papers since 1878. The journal aims to expand its scope by including studies that shed light on disease mechanisms and conducting innovative clinical trials for brain disorders. With a wide range of topics covered, the Editorial Board represents the international readership and diverse coverage of the journal. Accepted articles are promptly posted online, typically within a few weeks of acceptance. As of 2022, Brain holds an impressive impact factor of 14.5, according to the Journal Citation Reports.