Global, regional, and national burden of heart failure and its underlying causes, 1990-2021: results from the global burden of disease study 2021.

IF 9.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarker Research Pub Date : 2025-01-23 DOI:10.1186/s40364-025-00728-8

Jun Ran, Ping Zhou, Jinxi Wang, Xuemei Zhao, Yan Huang, Qiong Zhou, Mei Zhai, Yuhui Zhang

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Abstract

Background: Heart failure (HF) remains a significant public health challenge globally. This study aims to systematically analyze the global HF disease burden from 1990 to 2021 across temporal, spatial, and demographic dimensions to provide evidence for targeted prevention and control strategies.

Methods: Using data from the Global Burden of Disease (GBD) 2021 study, we analyzed the global HF burden through prevalent cases, years lived with disability (YLDs), and age-standardized rates per 100,000 population. Temporal trends were evaluated using estimated annual percentage change (EAPC) and joinpoint regression analysis. The relationship between the Socio-demographic Index (SDI) and disease burden was explored through Pearson correlation analysis, while attribution analysis identified the main causes of HF. When appropriate, analyses were stratified by 5 SDI regions, 21 GBD regions, 204 countries and territories, 20 age groups, and both sexes.

Results: Global HF prevalence and YLDs burden showed substantial increases from 1990 to 2021, with age-standardized prevalence increasing from 641.14 to 676.68 per 100,000 population. Notably, high-SDI regions exhibited a declining burden since 2019, indicating a potential global turning point. High-income North America bears the heaviest burden while South Asia shows the fastest growth rate. The correlation between disease burden and SDI level was negligible. The disease burden in males consistently exceeded that in females, with prevalence and YLDs rates rising sharply after age 60. The main causes and their attributable proportions were: ischemic heart disease (34.53%), hypertensive heart disease (22.53%), other cardiomyopathies (7.61%), chronic obstructive pulmonary disease (6.51%), and congenital heart anomalies (5.69%), with their distribution patterns differing across age groups and regions.

Conclusion: Global burden of HF increased significantly over recent decades, with a potential turning point in 2019 and marked regional disparities. It is essential to prioritize regions with heavy burdens or rapid growth rates, strengthen the management of major causes, and monitor HF burden trends in the post-COVID era.

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1990-2021年全球、区域和国家心力衰竭负担及其根本原因：来自2021年全球疾病负担研究的结果

背景：心力衰竭（HF）仍然是全球重大的公共卫生挑战。本研究旨在系统分析1990 - 2021年全球HF疾病负担的时间、空间和人口维度，为有针对性的预防和控制策略提供证据。方法：利用全球疾病负担（GBD） 2021研究的数据，我们通过流行病例、残疾生活年数（YLDs）和每10万人的年龄标准化率分析了全球HF负担。使用估计年百分比变化（EAPC）和连接点回归分析来评估时间趋势。通过Pearson相关分析探讨社会人口统计指数（SDI）与疾病负担的关系，归因分析确定HF的主要原因。在适当的情况下，将分析按5个SDI地区、21个GBD地区、204个国家和地区、20个年龄组和两性进行分层。结果：从1990年到2021年，全球HF患病率和YLDs负担大幅增加，年龄标准化患病率从每10万人641.14人增加到676.68人。值得注意的是，自2019年以来，高sdi地区的负担有所下降，表明可能出现全球转折点。高收入的北美负担最重，而南亚的增长速度最快。疾病负担与SDI水平的相关性可以忽略不计。男性的疾病负担一直超过女性，60岁以后患病率和死亡率急剧上升。主要病因和归因比例分别为：缺血性心脏病（34.53%）、高血压心脏病（22.53%）、其他心肌病（7.61%）、慢性阻塞性肺疾病（6.51%）和先天性心脏异常（5.69%），各年龄段和地区的分布规律不同。结论：近几十年来，全球心力衰竭负担显著增加，2019年可能出现转折点，地区差异明显。必须优先考虑负担重或增长速度快的地区，加强对主要原因的管理，并监测后covid时代HF负担趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarker Research Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

15.80

自引率

1.80%

发文量

审稿时长

10 weeks

期刊介绍： Biomarker Research, an open-access, peer-reviewed journal, covers all aspects of biomarker investigation. It seeks to publish original discoveries, novel concepts, commentaries, and reviews across various biomedical disciplines. The field of biomarker research has progressed significantly with the rise of personalized medicine and individual health. Biomarkers play a crucial role in drug discovery and development, as well as in disease diagnosis, treatment, prognosis, and prevention, particularly in the genome era.