Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading

IF 3.4 3区医学 Q1 ORTHOPEDICS

JOR Spine Pub Date : 2025-01-23 DOI:10.1002/jsp2.70038

Ziye Qiu, Sixue Chen, Ningning Feng, Wenhao Li, Yukun Ma, Shibo Zhou, Guozheng Jiang, Yishu Zhou, Xing Yu, Yang Xiong

{"title":"Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading","authors":"Ziye Qiu, Sixue Chen, Ningning Feng, Wenhao Li, Yukun Ma, Shibo Zhou, Guozheng Jiang, Yishu Zhou, Xing Yu, Yang Xiong","doi":"10.1002/jsp2.70038","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Cervical degeneration involves many pathophysiological changes. Vertebral bone loss, sclerotic hyperplasia of the vertebral body and intervertebral disc degeneration (IDD) are most common degenerative factors. However, whether there is a correlation between changes in vertebral bone mass and IDD remains unclear. In this study, based on magnetic resonance imaging (MRI), Pfirrmann method was used to grade cervical disc degeneration, and vertebral bone quality (VBQ) was measured. The correlation between VBQ and IDD was analyzed, and its potential mechanism was discussed as well.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>From June 2019 to June 2023, clinical data of patients undergoing surgical treatment for cervical degenerative disc diseases (CDDD) in our department were retrospectively analyzed. Preoperative MRI was collected, the degree of IDD was assessed by Pfirrmann grading, and VBQ was measured by T1-weighted image of MRI. With VBQ score = 3.08 as the threshold, Spearman correlation analysis was used to quantified the correlation between IDD grade and VBQ, and multiple ordered Logistic regression analysis was used to evaluate the effect of VBQ on IDD grade.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The preoperative MRI data of 94 patients (male, 42; female, 52) with CDDD were collected. Spearman correlation analysis: When VBQ score ≤ 3.08, the IDD grade was negatively correlated with VBQ (<i>p</i> < 0.05, <i>r</i> = −0.153). When VBQ score > 3.08, the IDD grade was positively correlated with VBQ (<i>p</i> < 0.05, <i>r</i> = 0.306). Multiple ordered Logistic regression analysis: When VBQ score ≤ 3.08, the effect of VBQ on IDD was negatively correlated (<i>p</i> < 0.05, <i>β</i> = −0.597). When VBQ score > 3.08, the effect of VBQ on IDD was positively correlated (<i>p</i> < 0.05, <i>β</i> = 0.986).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Either excessive increased or decreased VBQ in the cervical spine may accelerate the progression of IDD. The reason may be that both abnormal interference from the VBQ may imbalance the cervical spinal biomechanics and compromise the absorption of nutrients in the disc, thus accelerating the IDD. Therefore, cervical VBQ may have a bidirectional effect on IDD.</p>\n </section>\n </div>","PeriodicalId":14876,"journal":{"name":"JOR Spine","volume":"8 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755347/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOR Spine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jsp2.70038","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ORTHOPEDICS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Cervical degeneration involves many pathophysiological changes. Vertebral bone loss, sclerotic hyperplasia of the vertebral body and intervertebral disc degeneration (IDD) are most common degenerative factors. However, whether there is a correlation between changes in vertebral bone mass and IDD remains unclear. In this study, based on magnetic resonance imaging (MRI), Pfirrmann method was used to grade cervical disc degeneration, and vertebral bone quality (VBQ) was measured. The correlation between VBQ and IDD was analyzed, and its potential mechanism was discussed as well.

Methods

From June 2019 to June 2023, clinical data of patients undergoing surgical treatment for cervical degenerative disc diseases (CDDD) in our department were retrospectively analyzed. Preoperative MRI was collected, the degree of IDD was assessed by Pfirrmann grading, and VBQ was measured by T1-weighted image of MRI. With VBQ score = 3.08 as the threshold, Spearman correlation analysis was used to quantified the correlation between IDD grade and VBQ, and multiple ordered Logistic regression analysis was used to evaluate the effect of VBQ on IDD grade.

Results

The preoperative MRI data of 94 patients (male, 42; female, 52) with CDDD were collected. Spearman correlation analysis: When VBQ score ≤ 3.08, the IDD grade was negatively correlated with VBQ (p < 0.05, r = −0.153). When VBQ score > 3.08, the IDD grade was positively correlated with VBQ (p < 0.05, r = 0.306). Multiple ordered Logistic regression analysis: When VBQ score ≤ 3.08, the effect of VBQ on IDD was negatively correlated (p < 0.05, β = −0.597). When VBQ score > 3.08, the effect of VBQ on IDD was positively correlated (p < 0.05, β = 0.986).

Conclusions

Either excessive increased or decreased VBQ in the cervical spine may accelerate the progression of IDD. The reason may be that both abnormal interference from the VBQ may imbalance the cervical spinal biomechanics and compromise the absorption of nutrients in the disc, thus accelerating the IDD. Therefore, cervical VBQ may have a bidirectional effect on IDD.

Abstract Image

查看原文本刊更多论文

Pfirrmann分级法判定颈椎骨质量与椎间盘退变呈正相关还是负相关？

目的：颈椎病变性涉及多种病理生理变化。椎体骨质流失、椎体硬化性增生和椎间盘退变（IDD）是最常见的退行性因素。然而，椎体骨量变化与IDD之间是否存在相关性尚不清楚。本研究在磁共振成像（MRI）的基础上，采用Pfirrmann法对颈椎间盘退变进行分级，并测量椎体骨质量（VBQ）。分析了VBQ与IDD的相关性，并探讨了其潜在机制。方法：回顾性分析2019年6月至2023年6月我科手术治疗颈退变性椎间盘病（CDDD）患者的临床资料。术前收集MRI，采用Pfirrmann分级法评估IDD程度，采用MRI t1加权像测量VBQ。以VBQ评分= 3.08为阈值，采用Spearman相关分析量化IDD分级与VBQ的相关性，采用多元有序Logistic回归分析评价VBQ对IDD分级的影响。结果：94例患者术前MRI资料(男42例；女性，52例)。Spearman相关分析：当VBQ评分≤3.08时，IDD分级与VBQ呈负相关（p r = -0.153）。当VBQ评分为bb0 3.08时，IDD分级与VBQ呈正相关（p r = 0.306）。多元有序Logistic回归分析：当VBQ评分≤3.08时，VBQ对IDD的影响呈负相关（p β = -0.597）。当VBQ评分为bb0 3.08时，VBQ对IDD的影响呈显著正相关（p β = 0.986）。结论：颈椎的VBQ过高或过低都可能加速IDD的进展。原因可能是来自VBQ的异常干扰可能会使颈椎生物力学失衡，损害椎间盘对营养物质的吸收，从而加速IDD。因此，宫颈VBQ可能对IDD有双向作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊