Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Q1 Health Professions

Animal models and experimental medicine Pub Date : 2025-01-22 DOI:10.1002/ame2.12551

Md. Rezaul Islam, Md. Ibrahim Khalil Al-Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran

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Abstract

Background

Neurodegenerative diseases (NDs), including Alzheimer‘s disease, Parkinson‘s disease, and Huntington‘s disease, are complex and challenging due to their intricate pathophysiology and limited treatment options.

Methods

This review systematically sourced articles related to neurodegenerative diseases, neurodegeneration, quercetin, and clinical studies from primary medical databases, including Scopus, PubMed, and Web of Science.

Results

Recent studies have included quercetin to impact the cellular and molecular pathways involved in neurodegeneration. Quercetin, a flavonoid abundant in vegetables and fruits, is gaining attention for its antioxidant, anti-inflammatory, and antiapoptotic properties. It regulates signaling pathways such as nuclear factor-κB (NF-κB), sirtuins, and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt). These pathways are essential for cellular survival, inflammation regulation, and apoptosis. Preclinical and clinical studies have shown that quercetin improves symptoms and pathology in neurodegenerative models, indicating promising outcomes.

Conclusions

The study explores the potential of incorporating laboratory research into practical medical treatment, focusing on quercetin‘s neuroprotective effects on NDs and its optimal dosage.

Abstract Image

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神经退行性疾病的靶向信号通路：槲皮素对神经保护的细胞和分子机制。

背景：神经退行性疾病（ndds），包括阿尔茨海默病、帕金森病和亨廷顿病，由于其复杂的病理生理和有限的治疗选择，是复杂和具有挑战性的。方法：本综述系统地从主要医学数据库中检索与神经退行性疾病、神经退行性疾病、槲皮素和临床研究相关的文章，包括Scopus、PubMed和Web of Science。结果：最近的研究发现槲皮素影响神经退行性变的细胞和分子通路。槲皮素是一种富含蔬菜和水果的类黄酮，因其抗氧化、抗炎和抗细胞凋亡的特性而受到关注。它调节核因子-κB （NF-κB）、sirtuins和磷脂酰肌醇3-激酶/蛋白激酶B （PI3K/Akt）等信号通路。这些途径对细胞存活、炎症调节和细胞凋亡至关重要。临床前和临床研究表明，槲皮素可以改善神经退行性模型的症状和病理，表明有希望的结果。结论：本研究探索了将实验室研究纳入实际医学治疗的潜力，重点研究了槲皮素对ndds的神经保护作用及其最佳剂量。

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