Human Papillomavirus Infection and Cytological Atypia in Female Allogeneic Hematopoietic Stem Cell Transplantation Recipients.

IF 5 2区医学 Q1 IMMUNOLOGY

Transplantation Pub Date : 2025-07-01 Epub Date: 2025-01-23 DOI:10.1097/TP.0000000000005323

Adela Saco, Sara Carbonell, Natalia Rakislova, Isabel Matas, Silvia Alòs, Sandra Hoya, María Suárez-Lledó, Katarzyna Darecka, Lia Sisuashvili, Lorena Marimon, Naiara Vega, Roser Esteve, Carmen Martínez, Cristina Martí, Ariel Glickman, Olga Balagué, Aureli Torne, Jaume Ordi, Marta Del Pino

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引用次数: 0

Abstract

Background: Female recipients of allogeneic hematopoietic stem cell transplantation are at high risk of developing human papillomavirus (HPV)-associated lesions and (pre)cancer. We describe the results of a cervical cancer screening program in these women.

Methods: From 2010 to 2022, 70 female recipients of allogeneic hematopoietic stem cell transplantation in our institution entered a standardized protocol of gynecological evaluation. HPV testing, Papanicolaou smear, and thorough gynecological examinations were conducted in all the women.

Results: The cumulative prevalence of HPV infection was 21.4% (15/70). Ten of 70 women (14.3%) had a positive HPV test result in the first gynecological evaluation and 5 additional women (7.1%) became positive during follow-up. Thirteen women (18.5%) presented cytohistological lesions (3 high-grade lesions and 10 low-grade lesions). Twenty-nine women (41.4%) showed HPV-negative reactive atypical abnormalities related to the conditioning treatment, which closely mimicked HPV-associated lesions, which spontaneously disappeared during follow-up.

Conclusions: Gynecological evaluation should be maintained over time, as a significant proportion of these women may become HPV positive during follow-up. Reactive benign, atypical changes related to the treatment, which closely mimic HPV-associated lesions, are a frequent finding in these women. HPV testing is a key tool for the evaluation of these patients, as it allows for identifying women at risk and excluding cytological mimickers.

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女性异基因造血干细胞移植受者的人乳头瘤病毒感染和细胞学异型性。

背景：女性异体造血干细胞移植受者发生人乳头瘤病毒（HPV）相关病变和（前）癌的风险很高。我们描述了这些妇女宫颈癌筛查项目的结果。方法：2010年至2022年，对我院70例女性异基因造血干细胞移植受者进行标准化妇科评价。所有妇女都进行了HPV检测、巴氏涂片和全面的妇科检查。结果：累计HPV感染率为21.4%（15/70）。70名妇女中有10名（14.3%）在第一次妇科评估中HPV检测结果呈阳性，另外5名妇女（7.1%）在随访期间呈阳性。13名女性（18.5%）出现细胞组织学病变（3例高级别病变，10例低级别病变）。29名女性（41.4%）表现出与调理治疗相关的hpv阴性反应性非典型异常，这与hpv相关病变非常相似，在随访期间自发消失。结论：妇科评估应保持一段时间，因为这些妇女中有很大一部分可能在随访期间成为HPV阳性。与治疗相关的反应性良性非典型改变，与hpv相关病变非常相似，在这些女性中经常发现。HPV检测是评估这些患者的关键工具，因为它可以识别有风险的妇女并排除细胞学模拟者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation 医学-免疫学

CiteScore

8.50

自引率

11.30%

发文量

1906

审稿时长

1 months

期刊介绍： The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.