Temporal order of atrial fibrillation and acute myocardial infarction and associated prognosis in the Danish Diet, Cancer and Health cohort.

IF 2.8 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Open Heart Pub Date : 2025-01-21 DOI:10.1136/openhrt-2024-003132

Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J Benjamin, Anja Olsen, Henrik Kjærulf Jensen, Christina C Dahm

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引用次数: 0

Abstract

Background: Atrial fibrillation (AF) and acute myocardial infarction (AMI) share risk factors and are bidirectionally associated. Several studies found higher risks of outcomes in individuals with both conditions. Whether the risks of outcomes differ according to temporal order of AF and AMI is unclear.

Methods: The study was based on the Danish Diet, Cancer and Health cohort. We assessed the risk of heart failure (HF), ischaemic stroke (IS) and all-cause mortality during 10 years of follow-up in participants with both AF and AMI compared with only one and according to the temporal order of AF and AMI in participants with both conditions.

Results: We identified 5816 participants with newly diagnosed AF only, 3448 with first AMI only, 348 with AF before AMI and 721 participants with AMI before AF. The multivariable-adjusted risks of HF, IS and all-cause mortality were higher among participants with both AF and AMI compared with participants with only AF or AMI. In participants with both, there was no difference in risk of HF (HR 0.92, 95% CI 0.72 to 1.17) or IS (HR 1.12, 95% CI 0.76 to 1.66) between participants with AF before AMI compared with AMI before AF. AMI before AF was associated with lower all-cause mortality compared with AF before AMI (HR 0.70, 95% CI 0.54 to 0.90).

Conclusions: Risks of adverse outcomes were higher among participants with both AF and AMI compared with only AF or AMI. All-cause mortality, but not risk of HF or IS, differed according to temporal order with a lower mortality among participants with AMI before AF.

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来源期刊

Open Heart CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.60

自引率

3.70%

发文量

145

审稿时长

20 weeks

期刊介绍： Open Heart is an online-only, open access cardiology journal that aims to be “open” in many ways: open access (free access for all readers), open peer review (unblinded peer review) and open data (data sharing is encouraged). The goal is to ensure maximum transparency and maximum impact on research progress and patient care. The journal is dedicated to publishing high quality, peer reviewed medical research in all disciplines and therapeutic areas of cardiovascular medicine. Research is published across all study phases and designs, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Opinionated discussions on controversial topics are welcomed. Open Heart aims to operate a fast submission and review process with continuous publication online, to ensure timely, up-to-date research is available worldwide. The journal adheres to a rigorous and transparent peer review process, and all articles go through a statistical assessment to ensure robustness of the analyses. Open Heart is an official journal of the British Cardiovascular Society.