Evaluation of the significance of single nucleotide polymorphisms of the ABCB11 gene as biomarkers of hepatological complications in Epstein-Barr virus infection in children.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Experimental Hepatology Pub Date : 2024-03-01 Epub Date: 2024-06-11 DOI:10.5114/ceh.2024.140450

Justyna Moppert, Krzysztof Domagalski, Małgorzata Pawłowska

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Abstract

Aim of the study: To evaluate single nucleotide polymorphisms of the adenosine triphosphate (ATP) binding cassette subfamily B member 11 (ABCB11) gene, rs11568364 and rs2287622, as potential predictors of hepatologic complications during Epstein-Barr virus (EBV) infection among children.

Material and methods: The study group consisted of 54 children aged 1 to 18 years hospitalised from 01.12.2018 to 31.12.2020 in the Department of Paediatrics, Infectious Diseases and Hepatology with hepatological complications in the course of serologically and molecularly confirmed EBV infection. Real-time PCR using TaqMan probes was used to determine single-nucleotide variability in the ABCB11 gene.

Results: It was found that the presence of the T allele for the rs2287622 marker increases the probability of hepatitis three times and the possibility of hepatitis with cholestasis almost four times in EBV-infected patients.

Conclusions: The rs2287622 polymorphism of the ABCB11 gene appears to have an impact on the occurrence of hepatological complications in the course of EBV infection in children.

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评估ABCB11基因单核苷酸多态性作为eb病毒感染儿童肝脏并发症生物标志物的意义

研究目的：评估三磷酸腺苷（ATP）结合盒亚家族B成员11 （ABCB11）基因rs11568364和rs2287622的单核苷酸多态性作为eb病毒（EBV）感染儿童肝脏并发症的潜在预测因子。材料和方法：研究组包括54名1至18岁的儿童，于2018年12月1日至2020年12月31日在儿科、传染病和肝病科住院，在血清学和分子学证实的EBV感染过程中出现肝病并发症。采用TaqMan探针进行实时PCR检测ABCB11基因的单核苷酸变异。结果：发现rs2287622标记T等位基因的存在使ebv感染患者发生肝炎的可能性增加3倍，发生胆汁淤积型肝炎的可能性增加近4倍。结论：ABCB11基因rs2287622多态性可能对儿童EBV感染过程中肝脏并发症的发生有影响。

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来源期刊

Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： Clinical and Experimental Hepatology – quarterly of the Polish Association for Study of Liver – is a scientific and educational, peer-reviewed journal publishing original and review papers describing clinical and basic investigations in the field of hepatology.