Tumor-nerve interactions in cancer regulation and progression

IF 10.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-01-20 DOI:10.1016/j.canlet.2025.217483

Jianyi Zhao , Lilin Cheng , Jian Yang , Feifei Xu , Weixiang Qi , Keman Liao , Li Zhou , Lu Cao , Jiayi Chen , Yingying Lin

引用次数: 0

Abstract

Tumor-nerve interactions play a critical role in tumor progression, metastasis, and treatment resistance, redefining our understanding of the tumor microenvironment. This review provides a comprehensive analysis of how the peripheral and central nervous systems contribute to cancer biology, focusing on mechanisms of neural invasion, immune evasion, and tumor adaptation. It has highlighted the emerging potential of repurposing nervous system-targeted drugs originally developed for neurodegenerative and autoimmune diseases as innovative cancer therapies. The review also addresses key challenges, including the limitations of current experimental models and the complexity of translating preclinical findings to clinical applications. By bridging the gap between neuroscience and oncology, this interdisciplinary study aims to discover novel therapeutic strategies to improve outcomes for cancer patients.

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肿瘤-神经相互作用在肿瘤调控和进展中的作用。

肿瘤-神经相互作用在肿瘤进展、转移和治疗抵抗中起着关键作用，重新定义了我们对肿瘤微环境的理解。本文综述了外周和中枢神经系统在癌症生物学中的作用，重点介绍了神经入侵、免疫逃避和肿瘤适应的机制。它强调了将神经系统靶向药物重新用于神经退行性疾病和自身免疫性疾病作为创新癌症治疗的新兴潜力。该综述还指出了主要挑战，包括当前实验模型的局限性以及将临床前研究结果转化为临床应用的复杂性。通过弥合神经科学和肿瘤学之间的差距，这项跨学科研究旨在发现新的治疗策略，以改善癌症患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.