Decoding the Role of Kinesin Superfamily Proteins in Glioma Progression

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Mohamed J. Saadh, Zahraa Sabah Ghnim, Morug Salih Mahdi, Muktesh Chandra, Suhas Ballal, Lakshay Bareja, Kamlesh Chaudhary, R. S. K. Sharma, Sofia Gupta, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Atheer Khdyair Hamad
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Abstract

Glioma is a highly aggressive and invasive brain tumor with limited treatment options, highlighting the need for novel therapeutic approaches. Kinesin superfamily proteins (KIFs) are a diverse group of motor proteins that play essential roles in cellular processes such as mitosis, intracellular transport, and signal transduction, all of which are crucial for tumorigenesis. This review focuses on the multifaceted role of KIFs in glioma, examining their clinical relevance, contribution to tumor progression, and potential as therapeutic targets. We discuss how KIFs influence key aspects of glioma biology, including cell proliferation, invasion, migration, and metastasis. Furthermore, we explore the regulation of the cell cycle and critical signaling pathways associated with glioma, such as PI3K-Akt, Wnt/β-catenin, and Hedgehog signaling by KIFs. The review also addresses the emerging interplay between KIFs and non-coding RNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), in glioma progression. Finally, we examine current therapeutic strategies targeting KIFs, including immunotherapy, chemotherapy, and small-molecule inhibitors, and their potential to improve treatment outcomes for glioma patients. By synthesizing these insights, this review underscores the significance of KIFs in glioma pathogenesis and their promise as novel therapeutic targets in the fight against glioma.

解码驱动蛋白超家族蛋白在胶质瘤进展中的作用。
胶质瘤是一种高度侵袭性和侵袭性的脑肿瘤,治疗方案有限,强调需要新的治疗方法。运动蛋白超家族蛋白(KIFs)是一组多样的运动蛋白,在细胞过程中发挥重要作用,如有丝分裂、细胞内运输和信号转导,所有这些都是肿瘤发生的关键。这篇综述的重点是KIFs在胶质瘤中的多方面作用,检查它们的临床相关性,对肿瘤进展的贡献,以及作为治疗靶点的潜力。我们讨论了KIFs如何影响胶质瘤生物学的关键方面,包括细胞增殖、侵袭、迁移和转移。此外,我们探索了KIFs对细胞周期和与胶质瘤相关的关键信号通路的调控,如PI3K-Akt、Wnt/β-catenin和Hedgehog信号通路。该综述还讨论了kif和非编码rna(包括环状rna (circRNAs)和微rna (miRNAs))在胶质瘤进展中的相互作用。最后,我们研究了目前针对KIFs的治疗策略,包括免疫疗法、化疗和小分子抑制剂,以及它们改善胶质瘤患者治疗结果的潜力。通过综合这些见解,本综述强调了KIFs在胶质瘤发病机制中的重要性,以及它们作为对抗胶质瘤的新治疗靶点的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Molecular Neuroscience
Journal of Molecular Neuroscience 医学-神经科学
CiteScore
6.60
自引率
3.20%
发文量
142
审稿时长
1 months
期刊介绍: The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.
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