Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

IF 5.1 1区 化学 Q1 POLYMER SCIENCE
Davide Mazzali, Gabriela Rath, Alexander Röntgen, Vaidehi Roy Chowdhury, Michele Vendruscolo, Marina Resmini
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引用次数: 0

Abstract

Nanogels offer unique advantages, like high surface-to-volume ratio, scalable synthetic methods, and easily tailored formulations, that allow us to control size and introduce stimuli-responsive properties. Their potential for drug delivery is significant due to their biocompatibility, high drug loading capacity, and controlled and sustained drug release. The development of greener and sustainable processes is essential for large-scale applications. We report the synthesis in water of covalently cross-linked acrylamide-based nanogels, both neutral and negatively charged, with varying amounts of acryloyl-l-proline, using high-dilution radical polymerization, without the need for surfactants. The use of a water-based synthesis resulted in nanogels with high monomer conversions and chemical yields, as well as lower polydispersity and smaller particle sizes for the negatively charged nanogels, leading to a more efficient synthetic methodology, with reduced loss of starting materials, higher potential for scalability, and reduction in costs. The suitability of these nanogels for biomedical applications was supported by cytotoxicity studies showing no significant reduction in viability on a human neuroblastoma cell line.

Abstract Image

生物医学应用负电荷丙烯酰胺纳米凝胶的可持续和无表面活性剂合成
纳米凝胶具有独特的优势,如高表面体积比、可扩展的合成方法和易于定制的配方,使我们能够控制尺寸并引入刺激响应特性。由于其生物相容性、高载药能力和控制和持续的药物释放,它们的药物传递潜力是显著的。绿色和可持续工艺的发展对于大规模应用至关重要。我们报道了在水中合成共价交联的基于丙烯酰胺的纳米凝胶,中性和带负电荷,含有不同数量的丙烯酰-l-脯氨酸,使用高稀释自由基聚合,不需要表面活性剂。水基合成技术的使用使纳米凝胶具有高单体转化率和化学产率,并且具有更低的多分散性和更小的负电荷纳米凝胶粒径,从而导致更有效的合成方法,减少了起始材料的损失,具有更高的可扩展性潜力,并降低了成本。细胞毒性研究表明,这些纳米凝胶在人类神经母细胞瘤细胞系上的生存能力没有显著降低,这支持了这些纳米凝胶在生物医学应用中的适用性。
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来源期刊
Macromolecules
Macromolecules 工程技术-高分子科学
CiteScore
9.30
自引率
16.40%
发文量
942
审稿时长
2 months
期刊介绍: Macromolecules publishes original, fundamental, and impactful research on all aspects of polymer science. Topics of interest include synthesis (e.g., controlled polymerizations, polymerization catalysis, post polymerization modification, new monomer structures and polymer architectures, and polymerization mechanisms/kinetics analysis); phase behavior, thermodynamics, dynamic, and ordering/disordering phenomena (e.g., self-assembly, gelation, crystallization, solution/melt/solid-state characteristics); structure and properties (e.g., mechanical and rheological properties, surface/interfacial characteristics, electronic and transport properties); new state of the art characterization (e.g., spectroscopy, scattering, microscopy, rheology), simulation (e.g., Monte Carlo, molecular dynamics, multi-scale/coarse-grained modeling), and theoretical methods. Renewable/sustainable polymers, polymer networks, responsive polymers, electro-, magneto- and opto-active macromolecules, inorganic polymers, charge-transporting polymers (ion-containing, semiconducting, and conducting), nanostructured polymers, and polymer composites are also of interest. Typical papers published in Macromolecules showcase important and innovative concepts, experimental methods/observations, and theoretical/computational approaches that demonstrate a fundamental advance in the understanding of polymers.
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