Photo-crosslinking of doped magic-sized nanoclusters for the construction of enhanced electrochemiluminescence biosensors†

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2025-01-22 DOI:10.1039/D4SC07800D

Junjun Ge, Tengyue Yin, Haoyang Zhang, Yue Cao, Juan Liu, Jun-Jie Zhu, Yang Zhou and Yuanyuan Wang

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Abstract

Semiconductor magic-sized nanoclusters (MSCs) possess atomic-level compositional precision and ultrasmall dimensions, allowing accurate modulation of electrochemiluminescence (ECL) properties, essential for advanced bioanalytical applications. However, low intrinsic ECL intensity and poor stability in bipolar electrode (BPE)-ECL systems hinder their broader use. In this work, we addressed these limitations through doping and direct optical crosslinking strategies, achieving a 24-fold boost in the ECL signal and a fivefold stability increase for doped (CdS)₃₄:Ag MSCs compared with original (CdS)₃₄ MSCs. The resulting BPE-ECL biosensing platform was used for the sensitive detection of glucose with a linear detection range of 10 μM to 1 mM and a detection limit of 3.64 μM. This approach provides a robust strategy to enhance MSC-based ECL biosensing, paving the way for ultrasensitive, stable biosensors for clinical diagnostics and bioanalysis.

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掺杂魔术级纳米团簇的光交联构建增强电化学发光生物传感器

半导体魔术级纳米团簇（MSCs）具有原子级的组成精度和超小尺寸，允许精确调制电化学发光（ECL）特性，这对于先进的生物分析应用至关重要。然而，双极电极(BPE)-ECL系统固有ECL强度低，稳定性差，阻碍了其广泛应用。在这项工作中，我们通过掺杂和直接光学交联策略解决了这些限制，与原始（CdS）34 MSCs相比，掺杂（CdS）34:Ag MSCs的ECL信号增强了24倍，稳定性提高了5倍。所构建的BPE-ECL生物传感平台用于葡萄糖的灵敏检测，线性检测范围为10 μM ~ 1 mM，检出限为3.64 μM。这种方法提供了一种强大的策略来增强基于msc的ECL生物传感，为临床诊断和生物分析的超灵敏、稳定的生物传感器铺平了道路。

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.