C57BL/6J and C57BL/6N mice show distinct aging-associated behavioral alterations

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2025-02-01 DOI:10.1016/j.jphs.2025.01.002

Rui Yamada , Hirotaka Nagai , Io Horikawa , Wenran Qiu , Yunhui Zhu , Kohei Ota , Tomoyuki Furuyashiki

引用次数: 0

Abstract

Aging affects emotional, cognitive, and social functions, increasing susceptibility to neuropsychiatric conditions. C57BL/6 mice are commonly used to study aging mechanisms, yet differences between C57BL/6J and C57BL/6N substrains remain underexplored. This study compared aging-related behavioral changes in these substrains. Aging reduced exploratory activity and heightened anxiety in C57BL/6J, but not C57BL/6N, mice. Conversely, aging reduced social novelty preference in C57BL/6N, but not C57BL/6J, mice. Male mice of both substrains exhibited increased female urine sniffing with age. These findings highlight substrain-specific aging effects, underscoring the importance of substrain selection in behavioral studies of aged mice for drug development.

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C57BL/6J和C57BL/6N小鼠表现出明显的衰老相关行为改变。

衰老影响情感、认知和社会功能，增加对神经精神疾病的易感性。C57BL/6小鼠通常用于研究衰老机制，但C57BL/6J和C57BL/6N亚型之间的差异尚未得到充分研究。这项研究比较了这些亚菌株中与衰老相关的行为变化。衰老降低了C57BL/6J小鼠的探索活动和焦虑升高，但C57BL/6N小鼠没有。相反，衰老会降低C57BL/6N小鼠的社会新颖性偏好，而C57BL/6J小鼠则不会。随着年龄的增长，这两个亚系的雄性小鼠都表现出雌性嗅尿的增加。这些发现强调了底菌株特异性衰老效应，强调了在老年小鼠行为研究中选择底菌株对药物开发的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.