Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions

IF 4.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Neurochemistry Pub Date : 2025-01-18 DOI:10.1111/jnc.16311

Jiayou Jiang, Yunqian Zhang, Jiyi Wang, Yixin Qin, Chonguang Zhao, Kai He, Chaoming Wang, Yucheng Liu, Haoyu Feng, Huiling Cai, Shulei He, Ruiyu Li, David S. Galstyan, Longen Yang, Lee Wei Lim, Murilo S. de Abreu, Allan V. Kalueff

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Abstract

Epitranscriptomic regulation of cell functions involves multiple post-transcriptional chemical modifications of coding and non-coding RNA that are increasingly recognized in studying human brain disorders. Although rodent models are presently widely used in neuroepitranscriptomic research, the zebrafish (Danio rerio) has emerged as a useful and promising alternative model species. Mounting evidence supports the importance of RNA modifications in zebrafish CNS function, providing additional insights into epitranscriptomic mechanisms underlying a wide range of brain disorders. Here, we discuss recent data on the role of RNA modifications in CNS regulation, with a particular focus on zebrafish models, as well as evaluate current problems, challenges, and future directions of research in this field of molecular neurochemistry.

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利用斑马鱼模型研究中枢神经系统功能的表转录组调控。

细胞功能的表转录组调控涉及编码和非编码RNA的多种转录后化学修饰，这在人类大脑疾病的研究中越来越被认识到。虽然啮齿类动物模型目前广泛用于神经表转录组学研究，但斑马鱼（Danio rerio）已成为一种有用且有前途的替代模型物种。越来越多的证据支持RNA修饰在斑马鱼中枢神经系统功能中的重要性，为广泛的脑部疾病背后的表转录组学机制提供了更多的见解。在这里，我们讨论了关于RNA修饰在中枢神经系统调节中的作用的最新数据，特别关注斑马鱼模型，并评估了分子神经化学领域当前的问题、挑战和未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurochemistry 医学-神经科学

CiteScore

9.30

自引率

2.10%

发文量

181

审稿时长

2.2 months

期刊介绍： Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.