Diabetic microvascular complications are associated with left ventricular hypertrophy in patients with type 2 diabetes mellitus.

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-12-29 DOI:10.1016/j.jdiacomp.2024.108947

Simo Liu, Jing Ke, Xiaotong Feng, Yongsong Xu, Lin Zhu, Longyan Yang, Dong Zhao

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Abstract

Background: Left ventricular hypertrophy (LVH) is an important and common pathologic change in the heart of patients with diabetes mellitus. Microvascular complications have been reported to be involved in the development and process of LVH. This study aimed to explore the association between diabetic microvascular complications and LVH in patients with type 2 diabetes mellitus (T2DM).

Material and methods: This is a cross-sectional study. A total of 2912 patients with T2DM were enrolled, including 360 patients with LVH and 2552 patients without LVH. Demographic data, medical history and laboratory indices were collected, along with information on diabetic microvascular complications and results from cardiac ultrasonography. The study utilized multivariable logistic regression to evaluate the independent effects of microvascular complications (DR, DPN, or DKD) and the cumulative number of these complications on the presence of LVH, while adjusting for potential confounding factors.

Result: In patients with T2DM, those with LVH were older and had higher body mass index, waist circumference and hip circumference than those without LVH. Additionally, the proportion of patients with diabetic retinopathy (DR) and diabetic kidney disease (DKD) was larger among those with LVH compared to those without LVH. After adjusting for potential confounding factors, DR and DKD were associated with increased odds of LVH (odds ratio [OR] = 1.351 and OR = 1.404, respectively). The risk of LVH also increased progressively in patients with two or more diabetic microvascular conditions compared to those with only one. In subgroup analysis, the risk of LVH increased with the number of microvascular conditions in male patients with T2DM.

Conclusions: Diabetic microvascular complications were significantly associated with LVH in T2DM. Moreover, the risk of LVH increased with the number of microvascular complications, particularly in males with T2DM.

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糖尿病微血管并发症与2型糖尿病患者左心室肥厚有关。

背景：左心室肥厚（LVH）是糖尿病患者心脏重要而常见的病理改变。微血管并发症已被报道参与LVH的发展和过程。本研究旨在探讨2型糖尿病（T2DM）患者糖尿病微血管并发症与LVH的关系。材料和方法：这是一项横断面研究。共纳入2912例T2DM患者，其中伴有LVH患者360例，无LVH患者2552例。收集人口统计资料、病史和实验室指标，以及糖尿病微血管并发症和心脏超声检查结果。本研究利用多变量logistic回归来评估微血管并发症（DR、DPN或DKD）和这些并发症的累积数量对LVH存在的独立影响，同时调整潜在的混杂因素。结果：T2DM患者中，LVH患者年龄较大，体重指数、腰围、臀围均高于无LVH患者。此外，LVH患者中糖尿病视网膜病变（DR）和糖尿病肾病（DKD）的比例高于无LVH患者。在调整了潜在的混杂因素后，DR和DKD与LVH的几率增加相关（比值比[OR]分别= 1.351和1.404）。与只有一种糖尿病微血管疾病的患者相比，有两种或两种以上糖尿病微血管疾病的患者LVH的风险也逐渐增加。在亚组分析中，男性T2DM患者发生LVH的风险随着微血管病变数量的增加而增加。结论：糖尿病微血管并发症与T2DM患者LVH显著相关。此外，LVH的风险随着微血管并发症的增加而增加，尤其是在男性T2DM患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.