What does cancer screening have to do with tomato growing?

IF 3.8 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Miyo K Chatanaka, Eleftherios P Diamandis
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Abstract

Cancer screening is considered to be a major strategy for combatting cancer. The United States Preventive Services Task Force (USPSTF) recommends screening for five cancers, but the strength of evidence about the effectiveness of screening is limited. To gain insights into the efficacy of early detection requires prospective, blinded, placebo-controlled clinical trials with decades of follow-up and inclusion of millions of participants. Recently, Bretthauer et al. estimated lifetime gained with cancer screening tests by using a meta-analysis of 18 large randomized clinical trials which included more than two million subjects. They asked if cancer screening tests are saving lives and how much life is extended due to commonly used cancer screening tests. Colorectal cancer screening with sigmoidoscopy prolonged lifetime by 110 days, while fecal testing and mammography screening did not prolong life. A modest extension of 37 days was noted for prostate cancer screening with prostate-specific antigen testing and 107 days with lung cancer screening using computed tomography, but these estimates were not statistically significant. The authors concluded that current cancer screening strategies do not significantly prolong life. Based on these data, and the known biological behavior of some cancers, we hypothesized that the current strategies of treating cancer, after detection, could be modified to avoid the side effects of screening, which is a major determinant of the patient's overall survival.

癌症筛查与番茄种植有什么关系?
癌症筛查被认为是对抗癌症的主要策略。美国预防服务工作组(USPSTF)建议对五种癌症进行筛查,但关于筛查有效性的证据强度有限。为了深入了解早期检测的疗效,需要进行前瞻性、盲法、安慰剂对照的临床试验,随访数十年,包括数百万参与者。最近,Bretthauer等人通过对包括200多万受试者的18项大型随机临床试验进行荟萃分析,估计了癌症筛查试验获得的寿命。他们询问癌症筛查是否能挽救生命,以及常用的癌症筛查能延长多少生命。结肠直肠癌乙状结肠镜检查可延长寿命110天,而粪便检查和乳房x光检查不能延长寿命。前列腺特异性抗原检测的前列腺癌筛查延长了37天,计算机断层扫描的肺癌筛查延长了107天,但这些估计没有统计学意义。作者得出结论,目前的癌症筛查策略并不能显著延长寿命。基于这些数据,以及已知的一些癌症的生物学行为,我们假设目前的治疗癌症的策略,在检测后,可以进行修改,以避免筛查的副作用,这是患者总体生存的主要决定因素。
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来源期刊
Clinical chemistry and laboratory medicine
Clinical chemistry and laboratory medicine 医学-医学实验技术
CiteScore
11.30
自引率
16.20%
发文量
306
审稿时长
3 months
期刊介绍: Clinical Chemistry and Laboratory Medicine (CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor over 3. CCLM is issued monthly, and it is published in print and electronically. CCLM is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and publishes regularly EFLM recommendations and news. CCLM is the official journal of the National Societies from Austria (ÖGLMKC); Belgium (RBSLM); Germany (DGKL); Hungary (MLDT); Ireland (ACBI); Italy (SIBioC); Portugal (SPML); and Slovenia (SZKK); and it is affiliated to AACB (Australia) and SFBC (France). Topics: - clinical biochemistry - clinical genomics and molecular biology - clinical haematology and coagulation - clinical immunology and autoimmunity - clinical microbiology - drug monitoring and analysis - evaluation of diagnostic biomarkers - disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes) - new reagents, instrumentation and technologies - new methodologies - reference materials and methods - reference values and decision limits - quality and safety in laboratory medicine - translational laboratory medicine - clinical metrology Follow @cclm_degruyter on Twitter!
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