Mast cells: key players in digestive system tumors and their interactions with immune cells.

IF 6.1 2区 生物学 Q1 CELL BIOLOGY
Feihong Shu, Jie Yu, Youjia Liu, Fang Wang, Guoyou Gou, Min Wen, Chen Luo, Xianmin Lu, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie
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Abstract

Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune diseases. Recent studies in tumor-related research have demonstrated that mast cells exert a substantial influence on tumor cell behavior and the tumor microenvironment, exhibiting both pro- and anti-tumor effects. Specifically, mast cells not only secrete mediators related to pro-tumor function such as trypsin-like enzymes, chymotrypsin, vascular endothelial cell growth factor and histamine, but also mediators related to anti-tumor progression such as cystatin C and IL-17F. This dual role of mast cells renders them an under-recognized but very promising target for tumor immunotherapy. Digestive system tumors, characterized by high morbidity and associated mortality rates globally, are increasingly recognized as a significant healthcare burden. This paper examines the influence of mast cell-derived mediators on the development of tumors in the digestive system. It also explores the prognostic significance of mast cells in patients with various gastrointestinal cancers at different stages of the disease. Additionally, the article investigates the interactions between mast cells and immune cells, as well as the potential relationships among intratumoral bacteria, immune cells, and mast cell within digestive system microenvironment. The aim is to propose new strategies for the immunotherapy of digestive system tumors by targeting mast cells.

肥大细胞:消化系统肿瘤及其与免疫细胞相互作用的关键参与者。
肥大细胞(MCs)是先天免疫和适应性免疫过程的重要组成部分。它们在保护人类健康和各种疾病的病理生理学中发挥着重要作用,包括过敏、心血管疾病和自身免疫性疾病。近年来肿瘤相关研究表明,肥大细胞对肿瘤细胞行为和肿瘤微环境具有重要影响,表现出促肿瘤和抗肿瘤的双重作用。具体来说,肥大细胞不仅分泌胰蛋白酶样酶、凝乳胰蛋白酶、血管内皮细胞生长因子、组胺等促肿瘤功能相关的介质,还分泌胱抑素C、IL-17F等抗肿瘤进展相关的介质。肥大细胞的这种双重作用使它们成为肿瘤免疫治疗的一个未被认识但非常有希望的靶点。消化系统肿瘤,其特点是高发病率和相关死亡率在全球范围内,越来越被认为是一个重要的医疗负担。本文探讨肥大细胞源介质对消化系统肿瘤发生的影响。探讨肥大细胞在不同阶段胃肠道肿瘤患者中的预后意义。此外,本文还探讨了肥大细胞与免疫细胞之间的相互作用,以及消化系统微环境中肿瘤内细菌、免疫细胞和肥大细胞之间的潜在关系。目的是提出针对肥大细胞免疫治疗消化系统肿瘤的新策略。
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来源期刊
Cell Death Discovery
Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
8.30
自引率
1.40%
发文量
468
审稿时长
9 weeks
期刊介绍: Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.
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