Clinicopathologic characteristics of ductal carcinoma in situ and risk of subsequent invasive breast cancer: a multicenter, population-based cohort study.

IF 3 3区 医学 Q2 ONCOLOGY
Breast Cancer Research and Treatment Pub Date : 2025-04-01 Epub Date: 2025-01-20 DOI:10.1007/s10549-024-07599-x
Thomas E Rohan, Yihong Wang, Fergus Couch, Heather Spencer Feigelson, Robert T Greenlee, Stacey Honda, Azadeh Stark, Dhananjay Chitale, Chenxin Zhang, Xiaonan Xue, Mindy Ginsberg, Olivier Loudig
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引用次数: 0

Abstract

Purpose: To study the association between clinicopathologic characteristics of ductal carcinoma in situ (DCIS) and risk of subsequent invasive breast cancer (IBC).

Methods: We conducted a case-control study nested in a multicenter, population-based cohort of 8175 women aged ≥ 18 years with DCIS diagnosed between 1987 and 2016 and followed for a median duration of 83 months. Cases (n = 497) were women with a first diagnosis of DCIS who developed a subsequent IBC ≥ 6 months later; controls (2/case; n = 959) were matched to cases on age at and calendar year of DCIS diagnosis. Univariable and multivariable conditional logistic regression models were used to examine the associations between the DCIS characteristics of interest (non-screen detection of DCIS, tumor size, positive margins, grade of DCIS, necrosis, architectural pattern, microcalcification, and estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status) and risk of IBC.

Results: In the total study population, the associations were largely null. In subgroup analyses, there were strong position associations with punctate necrosis (pre/perimenopausal women), detection by physical exam (postmenopausal women), architectural patterns other than the main types (breast-conserving surgery [BCS]), and DCIS margins (ipsilateral cases), and inverse associations with HER2 positivity (BCS) and microcalcification (mastectomy); however, the associated confidence intervals were mostly very wide.

Conclusion: The results of this study provide limited support for associations of the DCIS clinicopathologic characteristics studied here and risk of IBC.

导管原位癌的临床病理特征和继发浸润性乳腺癌的风险:一项多中心、基于人群的队列研究
目的:探讨导管原位癌(ductal carcinoma in situ, DCIS)的临床病理特征与继发浸润性乳腺癌(invasive breast cancer, IBC)的关系。方法:我们在一个多中心、基于人群的队列中进行了一项病例对照研究,纳入了8175名年龄≥18岁、1987年至2016年间诊断为DCIS的女性,随访时间中位数为83个月。病例(n = 497)为首次诊断为DCIS并在6个月后发展为IBC的女性;控制(2 / case;n = 959)与DCIS诊断的年龄和日历年相匹配。使用单变量和多变量条件logistic回归模型来检查DCIS的相关特征(非筛查DCIS、肿瘤大小、阳性边缘、DCIS分级、坏死、建筑模式、微钙化、雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2 (HER2)状态)与IBC风险之间的关系。结果:在整个研究人群中,这些关联基本为零。在亚组分析中,体位与点状坏死(绝经前/围绝经期妇女)、体检发现(绝经后妇女)、主要类型以外的建筑模式(保乳手术[BCS])和DCIS边缘(同侧病例)有很强的相关性,与HER2阳性(BCS)和微钙化(乳房切除术)呈反比相关;然而,相关的置信区间大多非常宽。结论:本研究的结果为DCIS临床病理特征与IBC风险之间的关系提供了有限的支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
342
审稿时长
1 months
期刊介绍: Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.
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