Persistent NK cell deficiency associated with pulmonary cryptococcosis.

IF 4.6 2区医学 Q1 MICROBIOLOGY

Annals of Clinical Microbiology and Antimicrobials Pub Date : 2025-01-18 DOI:10.1186/s12941-024-00771-7

Martin Martinot, Shu Shun Li, Catherine Farnarier, Cléa Dubrou, Christelle Piperoglou, Christopher H Mody, Frederic Vely

引用次数: 0

Abstract

We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus.

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持久性NK细胞缺乏与肺隐球菌病有关。

我们描述了一个28岁以前健康男性的肺隐球菌病。详尽的免疫学研究显示，原发性NK细胞缺乏与继发性抗隐球菌CD8淋巴细胞反应受损和CD8Vβ14 + T细胞克隆扩增有关。这个病例说明了NK细胞在对隐球菌免疫中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Microbiology and Antimicrobials MICROBIOLOGY-

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of Clinical Microbiology and Antimicrobials considers good quality, novel and international research of more than regional relevance. Research must include epidemiological and/or clinical information about isolates, and the journal covers the clinical microbiology of bacteria, viruses and fungi, as well as antimicrobial treatment of infectious diseases. Annals of Clinical Microbiology and Antimicrobials is an open access, peer-reviewed journal focusing on information concerning clinical microbiology, infectious diseases and antimicrobials. The management of infectious disease is dependent on correct diagnosis and appropriate antimicrobial treatment, and with this in mind, the journal aims to improve the communication between laboratory and clinical science in the field of clinical microbiology and antimicrobial treatment. Furthermore, the journal has no restrictions on space or access; this ensures that the journal can reach the widest possible audience.