Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications.

IF 5.7 1区医学 Q1 CRITICAL CARE MEDICINE

Annals of Intensive Care Pub Date : 2025-01-17 DOI:10.1186/s13613-025-01434-2

Anaïs Curtiaud, Toshiaki Iba, Eduardo Angles-Cano, Ferhat Meziani, Julie Helms

引用次数: 0

Abstract

Diagnosing coagulopathy in septic patients remains challenging in intensive care. Disseminated intravascular coagulation (DIC) indeed presents with complex pathophysiology, complicating timely diagnosis. Epidemiological data indicate a significant prevalence of DIC in septic patients, with mortality rates up to 60%. Despite advances, current biomarker-based diagnostic tools often fail to provide early and accurate detection. This review evaluates the utility and limitations of traditional and emerging biomarkers for diagnosing sepsis-induced coagulopathy (SIC) and DIC. We also assess the effectiveness of anticoagulant therapy guided by biomarker-based diagnostic criteria.

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败血症引起的凝血病的生物标志物：诊断见解和潜在的治疗意义。

在重症监护中诊断败血症患者的凝血功能障碍仍然具有挑战性。弥散性血管内凝血（DIC）确实具有复杂的病理生理，使及时诊断变得复杂。流行病学数据表明，脓毒症患者中DIC的发生率很高，死亡率高达60%。尽管取得了进步，但目前基于生物标志物的诊断工具往往无法提供早期和准确的检测。本文综述了传统和新兴生物标志物在诊断败血症诱导凝血病（SIC）和DIC方面的应用和局限性。我们还评估了基于生物标志物的诊断标准指导下抗凝治疗的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Intensive Care CRITICAL CARE MEDICINE-

CiteScore

14.20

自引率

3.70%

发文量

107

审稿时长

13 weeks

期刊介绍： Annals of Intensive Care is an online peer-reviewed journal that publishes high-quality review articles and original research papers in the field of intensive care medicine. It targets critical care providers including attending physicians, fellows, residents, nurses, and physiotherapists, who aim to enhance their knowledge and provide optimal care for their patients. The journal's articles are included in various prestigious databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, OCLC, PubMed, PubMed Central, Science Citation Index Expanded, SCOPUS, and Summon by Serial Solutions.