The Role of the Dysregulation of circRNAs Expression in Glioblastoma Multiforme

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Molecular Neuroscience Pub Date : 2025-01-22 DOI:10.1007/s12031-024-02285-5

Yafei Wang, Ying Yu, Jiahua Yu, Cheng Wang, Yunkun Wang, Runxi Fu, Chenran Zhang

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引用次数: 0

Abstract

Primary brain tumors that were the most severe and aggressive were called glioblastoma multiforme (GBM). Cancers are caused in part by aberrant expression of circular RNA. Often referred to as competitive endogenous RNA (ceRNA), circRNA molecules act as “miRNA sponges” in cells by decreasing the inhibitory impact of miRNA on their target genes and hence raising the expression levels of those genes. circRNA molecules are rich in miRNA binding sites. The discovery of more structurally diverse and GBM-related circRNAs has great promise for the use of GMB prognostic biomarkers and therapeutic targets, as well as for comprehending the molecular regulatory mechanisms of GBM. In this work, we present an overview of the circRNA expression patterns associated with GBM and offer a potential integrated electrochemical strategy for detecting circRNA with extreme sensitivity in the diagnosis of glioblastoma.

Graphical Abstract

The circular RNA (circRNA) regulates both physiological and pathological processes in glioblastoma multiforme disease. Hence, it could serve as a biomarker as well as a therapeutic target.

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环状rna表达异常在多形性胶质母细胞瘤中的作用

最严重和侵袭性的原发性脑肿瘤被称为多形性胶质母细胞瘤（GBM）。癌症部分是由环状RNA的异常表达引起的。circRNA分子通常被称为竞争性内源性RNA (ceRNA)，它通过降低miRNA对靶基因的抑制作用，从而提高这些基因的表达水平，在细胞中充当“miRNA海绵”。circRNA分子含有丰富的miRNA结合位点。更多结构多样化和与GBM相关的环状rna的发现，对于使用GBM预后生物标志物和治疗靶点，以及理解GBM的分子调控机制具有很大的前景。在这项工作中，我们概述了与GBM相关的circRNA表达模式，并提供了一种潜在的集成电化学策略，可以在胶质母细胞瘤的诊断中以极高的灵敏度检测circRNA。环状RNA （circRNA）调节多形性胶质母细胞瘤疾病的生理和病理过程。因此，它可以作为生物标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Neuroscience 医学-神经科学

CiteScore

6.60

自引率

3.20%

发文量

142

审稿时长

1 months

期刊介绍： The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.