Features of the Formation of Complexes of \({\beta}\)-Carboxymethyl Cyclodextrins on the Surface of Lipid Monolayers

Abstract

In this study, the interaction of \(\beta\)-carboxymethyl cyclodextrins (CMCD) with monomolecular layers composed of a mixture of electroneutral and cationic lipids on the surface of an aqueous subphase was investigated. The monolayers were transferred onto mica substrates using the Langmuir–Blodgett method and examined by atomic force microscopy. Analysis of the monolayer compression isotherms and AFM images showed that the adsorption of CMCD on the cationic Langmuir lipid monolayer is accompanied by the formation of supramolecular ensembles of similar morphology regardless of the concentration of the added oligosaccharides.