Unveiling the Therapeutic Potential: Okra-Derived Flavonoids in Breast Cancer Treatment

Abstract

Introduction

The increased incidence and high global death rates of breast cancer make it a major global health problem. New therapeutic techniques are still needed, especially those that focus on certain molecular pathways that have been linked to the development and progression of breast cancer, even with the advancements in treatment strategy. Due to their wide range of biological activity and generally low safety profiles, chemicals originating from plants especially flavonoids, have shown promise as possible anti-cancer medicines.

Methods

We sought to determine if flavonoids from Abelmoschus esculentus (okra) seeds might prove useful in the treatment of breast cancer. Six major subgroups of flavonoids found in okra seeds were discovered after a thorough examination of the literature, and their potential anti-cancer benefits were investigated.

Results

Oestrogen receptor alpha (ESR1), protein kinase B (AKT1), and the epidermal growth factor receptor (EGFR) were among the proteins linked to breast cancer whose binding modes and affinities were predicted using molecular docking simulations. Moreover, genes that are differently expressed in breast cancer cell lines were found using high throughput gene sequencing data analysis.

Discussions

Based on our research, certain flavonoids from okra seeds could interact with important proteins that are involved in the initiation and spread of breast cancer, providing information on potential treatment strategies. However, more experimental validation is required to validate these results and clarify the therapeutic significance of flavonoids produced from okra in treating breast cancer.