Communicating hydrocephalus in glioblastoma presenting as chronic hydrocephalus: systematic review and meta-analysis

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-01-16 DOI:10.1007/s00701-024-06414-2

Rebeca Pérez-Alfayate, Santiago Cabezas-Camarero, Juan Pablo Castaño-Montoya, Ana Alejandra Arévalo-Saenz, Angela Carrascosa-Granada, Pedro Alonso-Lera, Giovanni Grasso

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引用次数: 0

Abstract

Objective

Communicating hydrocephalus (CH) is an uncommon complication that can affect patients with glioblastoma (GBM). Due to its clinical and radiological findings, it presents as a chronic hydrocephalus. The mechanisms underlying its occurrence and impact on the prognosis of the disease are poorly known, but some studies have suggested that shunting can have a positive impact on the quality of life of these patients.

Methods

The authors performed a systematic literature review and meta-analysis to identify the possible risk factors that could help to identify CH cases in glioblastoma, using the MEDLINE/PubMed and Cochrane Database of Systematic Reviews databases. The Joanna Briggs Institute critical appraisal tool was used to assess the risk of bias.

Results

Our search yielded 273 studies, but only 9 records were included in the final quantitative analysis. CH in glioblastoma patients was found to be very uncommon (proportion 0.04 out of 1; range 0.03–0.05, p < 0.01, CI:95%) and its occurrence was associated with a previous ventricular opening (0.85 out of 1; range 0.66–0.94, p < 0.01, CI:95%).

Conclusion

CH in glioblastoma should be suspected in patients with GBM who have undergone accidental ventricular opening during tumor resection and presenting with chronic hydrocephalus symptoms.

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胶质母细胞瘤中的交通性脑积水表现为慢性脑积水：系统回顾和荟萃分析

目的通讯性脑积水（CH）是胶质母细胞瘤（GBM）患者中一种罕见的并发症。由于其临床和影像学表现，它表现为慢性脑积水。其发生的机制和对疾病预后的影响尚不清楚，但一些研究表明，分流可以对这些患者的生活质量产生积极影响。方法使用MEDLINE/PubMed和Cochrane系统评价数据库，作者进行了系统的文献综述和荟萃分析，以确定可能有助于识别胶质母细胞瘤CH病例的危险因素。乔安娜布里格斯研究所的关键评估工具被用来评估偏见的风险。结果我们检索到273篇研究，但只有9篇记录被纳入最终的定量分析。在胶质母细胞瘤患者中发现CH非常罕见(比例0.04 / 1；范围0.03-0.05,p < 0.01, CI:95%)，其发生与既往心室开放相关(0.85 / 1；范围0.66-0.94,p < 0.01, CI:95%)。结论恶性胶质瘤患者在肿瘤切除过程中发生意外脑室打开并出现慢性脑积水症状时，应怀疑胶质母细胞瘤中的脑积水。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.