Epigenetic Regulation of Innate and Adaptive Immune Cells in Salt-Sensitive Hypertension.

IF 16.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation research Pub Date : 2025-01-16 DOI:10.1161/circresaha.124.325439

Ashley L Mutchler,Alexandria Porcia Haynes,Mohammad Saleem,Sydney Jamison,Mohd Mabood Khan,Lale Ertuglu,Annet Kirabo

引用次数: 0

Abstract

Access to excess dietary sodium has heightened the risk of cardiovascular diseases, particularly affecting individuals with salt sensitivity of blood pressure. Our research indicates that innate antigen-presenting immune cells contribute to rapid blood pressure increases in response to excess sodium intake. Emerging evidence suggests that epigenetic reprogramming, with subsequent transcriptional and metabolic changes, of innate immune cells allows these cells to have a sustained response to repetitive stimuli. Epigenetic mechanisms also steer T-cell differentiation in response to innate immune signaling. Immune cells respond to environmental and nutritional cues, such as salt, promoting epigenetic regulation changes. This article aims to identify and discuss the role of epigenetic mechanisms in the immune system contributing to salt-sensitive hypertension.

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盐敏感性高血压中先天和适应性免疫细胞的表观遗传调控。

饮食中摄入过量的钠增加了患心血管疾病的风险，特别是对血压对盐敏感的人。我们的研究表明，先天抗原呈递免疫细胞有助于快速血压升高，以应对过量的钠摄入。新出现的证据表明，先天免疫细胞的表观遗传重编程，以及随后的转录和代谢变化，使这些细胞对重复刺激有持续的反应。表观遗传机制也引导t细胞分化以响应先天免疫信号。免疫细胞对环境和营养因素（如盐）做出反应，促进表观遗传调控的变化。本文旨在确定和讨论表观遗传机制在免疫系统中对盐敏感性高血压的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation research 医学-外周血管病

CiteScore

29.60

自引率

2.00%

发文量

535

审稿时长

3-6 weeks

期刊介绍： Circulation Research is a peer-reviewed journal that serves as a forum for the highest quality research in basic cardiovascular biology. The journal publishes studies that utilize state-of-the-art approaches to investigate mechanisms of human disease, as well as translational and clinical research that provide fundamental insights into the basis of disease and the mechanism of therapies. Circulation Research has a broad audience that includes clinical and academic cardiologists, basic cardiovascular scientists, physiologists, cellular and molecular biologists, and cardiovascular pharmacologists. The journal aims to advance the understanding of cardiovascular biology and disease by disseminating cutting-edge research to these diverse communities. In terms of indexing, Circulation Research is included in several prominent scientific databases, including BIOSIS, CAB Abstracts, Chemical Abstracts, Current Contents, EMBASE, and MEDLINE. This ensures that the journal's articles are easily discoverable and accessible to researchers in the field. Overall, Circulation Research is a reputable publication that attracts high-quality research and provides a platform for the dissemination of important findings in basic cardiovascular biology and its translational and clinical applications.