eIF4F-mediated Dysregulation of mRNA Translation in Cancer.

IF 4.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

RNA Pub Date : 2025-01-14 DOI:10.1261/rna.080340.124

Mehdi Amiri, Niaz Mahmood, Soroush Tahmasebi, Nahum Sonenberg

引用次数: 0

Abstract

Messenger RNA (mRNA) translational control plays a pivotal role in regulating cellular proteostasis under physiological and pathological conditions. Dysregulated mRNA translation is pervasive in cancer, in which protein synthesis is elevated to support accelerated cell growth and proliferation. Consequently, targeting the mRNA translation machinery has emerged as a therapeutic strategy to treat cancer. In this perspective, we summarize the current knowledge of translation dysregulation in cancer, with emphasis on the eukaryotic translation initiation factor 4F (eIF4F) complex. We outline recent endeavors to apply this knowledge to develop novel treatment strategies to combat cancer.

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肿瘤中eif4f介导的mRNA翻译失调。

在生理和病理条件下，信使RNA （mRNA）的翻译控制在调节细胞的蛋白酶平衡中起着关键作用。mRNA翻译失调在癌症中普遍存在，其中蛋白质合成升高以支持加速细胞生长和增殖。因此，靶向mRNA翻译机制已成为治疗癌症的一种治疗策略。从这个角度来看，我们总结了目前对癌症翻译失调的了解，重点是真核翻译起始因子4F （eIF4F）复合物。我们概述了最近的努力，应用这些知识，以开发新的治疗策略，以对抗癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

RNA 生物-生化与分子生物学

CiteScore

8.30

自引率

2.20%

发文量

101

审稿时长

2.6 months

期刊介绍： RNA is a monthly journal which provides rapid publication of significant original research in all areas of RNA structure and function in eukaryotic, prokaryotic, and viral systems. It covers a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; alternative processing: cis-acting elements and trans-acting factors; ribosome structure and function; translational control; RNA catalysis; tRNA structure, function, biogenesis and identity; RNA editing; rRNA structure, function and biogenesis; RNA transport and localization; regulatory RNAs; large and small RNP structure, function and biogenesis; viral RNA metabolism; RNA stability and turnover; in vitro evolution; and RNA chemistry.