Neurofilament light chain level is associated with lifetime suicidal behaviors.

IF 4.5 2区医学 Q1 CLINICAL NEUROLOGY

International Journal of Neuropsychopharmacology Pub Date : 2025-01-15 DOI:10.1093/ijnp/pyaf003

Ying-Chih Cheng, Yu-Li Liu, Wen-Yin Chen, Chih-Chiang Chiu, Ming-Chyi Huang, Po-Hsiu Kuo

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引用次数: 0

Abstract

Background: Suicide is among the severe outcomes of mental illness and has been reported to be associated with neurodegeneration and cognitive impairment. The blood neurofilament light chain (NfL) level is a biomarker of neuronal damage in neuropsychiatric disorders. This study investigated whether the NfL levels are associated with lifetime suicidal behaviors and whether this level is higher in patients with major depressive disorder (MDD) compared with healthy controls.

Methods: In this cross-sectional study, we included 73 patients with MDD and 40 age- and sex-matched controls. The blood NfL levels were measured using an enzyme-linked immunosorbent assay. We compared the NfL levels between patients with MDD and controls and performed regression analysis to evaluate the association between the NfL levels and suicidal behaviors.

Results: Nearly half of the patients with MDD (43.80%) reported lifetime suicide attempts. Those with MDD had higher blood NfL levels, but their levels did not significantly differ from those of the healthy controls. Logistic regression results revealed higher risks of lifetime suicide planning (Odds ratio (OR) = 1.64) and suicide attempts (OR = 1.94) with every 10 pg/mL increase in the NfL levels.

Conclusions: Our results demonstrate that higher serum NfL levels were associated with lifetime suicidal behavior.

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神经丝轻链水平与终生自杀行为有关。

背景：自杀是精神疾病的严重后果之一，据报道与神经变性和认知障碍有关。血液神经丝轻链（NfL）水平是神经精神疾病神经元损伤的生物标志物。本研究调查了NfL水平是否与终生自杀行为相关，以及与健康对照相比，重度抑郁症（MDD）患者的NfL水平是否更高。方法：在这项横断面研究中，我们纳入了73名重度抑郁症患者和40名年龄和性别匹配的对照组。采用酶联免疫吸附法测定血液中NfL水平。我们比较了MDD患者和对照组的NfL水平，并进行回归分析以评估NfL水平与自杀行为之间的关系。结果：近一半的MDD患者（43.80%）报告一生中有自杀企图。重度抑郁症患者血液中NfL水平较高，但与健康对照组相比没有显著差异。Logistic回归结果显示，NfL水平每增加10 pg/mL，终生自杀计划（比值比(OR) = 1.64）和自杀企图（OR = 1.94）的风险就会增加。结论：我们的研究结果表明，较高的血清NfL水平与终生自杀行为有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Neuropsychopharmacology 医学-精神病学

CiteScore

8.40

自引率

2.10%

发文量

230

审稿时长

4-8 weeks

期刊介绍： The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.