Histone demethylases in autophagy and inflammation.

IF 8.2 2区生物学 Q1 CELL BIOLOGY

Cell Communication and Signaling Pub Date : 2025-01-13 DOI:10.1186/s12964-024-02006-w

Yaoyao Ma, Wenting Lv, Yi Guo, Tong Yin, Yujie Bai, Ziqi Liu, Chao Chen, WenjuanYang, Jiayi Feng, Wenbin Qian, Ruiling Tang, Yanting Su, Shigang Shan, Huifen Dong, Yongfen Bao, Lihua Qu

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引用次数: 0

Abstract

Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses. Among post-translational modifications, histone lysine methylation holds significant importance. There are over 30 members of histone lysine demethylases (KDMs), which act as epigenetic regulators in physiological processes and diseases. Importantly, KDMs are abnormally expressed in the regulation of cellular autophagy and inflammation, representing a crucial mechanism affecting inflammation-related diseases. This article reviewed the function of KDMs proteins in autophagy and inflammation. Specifically, It focused on the specific regulatory mechanisms underlying the activation or inhibition of autophagy, as well as their abnormal expression in inflammatory responses. By analyzing each KDM in epigenetic modification, this review provides a reliable theoretical basis for clinical decision marking regarding autophagy abnormalities and inflammatory diseases.

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自噬和炎症中的组蛋白去甲基化酶。

自噬功能障碍与自噬相关基因的改变有关。自噬与多种因素有关，调节自噬的机制非常复杂。表观遗传变化，如组蛋白去甲基化酶的异常表达，不仅与肿瘤发生密切相关，而且与炎症反应密切相关。在翻译后修饰中，组蛋白赖氨酸甲基化具有重要意义。组蛋白赖氨酸去甲基化酶（kdm）有30多个成员，在生理过程和疾病中起表观遗传调节作用。重要的是，kdm在细胞自噬和炎症的调节中异常表达，代表了影响炎症相关疾病的重要机制。本文就kdm蛋白在自噬和炎症中的作用作一综述。具体来说，它侧重于自噬激活或抑制的特定调节机制，以及它们在炎症反应中的异常表达。通过分析表观遗传修饰中的各种KDM，为自噬异常和炎症性疾病的临床决策标记提供可靠的理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.