The correlation study between posterior fossa crowding and classical trigeminal neuralgia

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-01-14 DOI:10.1007/s00701-025-06426-6

Yinzhan Wang, Yihui Du, Wenchang Guo, Yang Li, Haowei Shi, Zenghui Xi, Tao Qian

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引用次数: 0

Abstract

Objective

To explore the correlation between posterior fossa crowding and the occurrence of classical trigeminal neuralgia (TN).

Methods

A total of 60 patients diagnosed with classical TN and 60 age- and sex-matched healthy volunteers were included as a control group for a case-control study. All subjects underwent high-resolution 3D magnetic resonance imaging (MRI) examinations (including 3D-FIESTA and 3D-TOF MRA sequences). The original data were subjected to 3D reconstruction and measurement of posterior fossa volume (PFV) and hindbrain volume (HBV) using 3D-slicer software. The posterior fossa crowding index (PFCI) was calculated as HBV/PFV × 100%. Finally, data were analyzed using SPSS 22.0 statistical software.

Results

The average PFCI in patients with TN was 85.0% ± 3.9%, compared to 82.7% ± 3.9% in the control group, with a significant statistical difference (P = 0.025). Female patients with TN had a more crowded posterior fossa than male patients (86.4% ± 3.8% vs. 83.4% ± 3.4%, P = 0.033). Multiple linear regression analysis showed that a higher PFCI was associated with being female (P = 0.022), younger age (P = − 0.003), and being a patient with TN (P = − 0.023).

Conclusion

Patients with PTN have a more crowded posterior fossa compared to the healthy control group. A higher PFCI is associated with being female, younger age, and being a patient with TN. Posterior fossa crowding may be a risk factor for neurovascular conflict (NVC), making it more likely to lead to the occurrence of TN.

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后窝拥挤与经典三叉神经痛的相关性研究

目的探讨后窝拥挤与经典三叉神经痛（TN）发生的关系。方法选取60例经诊断为典型TN的患者和60例年龄、性别匹配的健康志愿者作为对照组，进行病例对照研究。所有受试者均行高分辨率三维磁共振成像（MRI）检查（包括3D- fiesta和3D- tof MRA序列）。使用3D切片软件对原始数据进行三维重建并测量后颅窝体积（PFV）和后脑体积（HBV）。后窝拥挤指数（PFCI）计算为HBV/PFV × 100%。最后，采用SPSS 22.0统计软件对数据进行分析。结果TN组患者平均PFCI为85.0%±3.9%，对照组为82.7%±3.9%，差异有统计学意义（P = 0.025）。女性TN患者后窝拥挤程度高于男性（86.4%±3.8% vs. 83.4%±3.4%,P = 0.033）。多元线性回归分析显示，PFCI较高与女性（P = 0.022）、年龄较小（P = - 0.003）、TN患者（P = - 0.023）相关。结论与健康对照组相比，PTN患者后颅窝更拥挤。较高的PFCI与女性、年轻和TN患者相关。后窝拥挤可能是神经血管冲突（NVC）的危险因素，使其更容易导致TN的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.