Reaction of Donor–Acceptor α-Diazo Esters and N,N-Dimethylformamide/γ-Lactams To Generate α-Amino-α-aroylethanoates

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-13 DOI:10.1021/acs.orglett.4c03771

Xiaonan Mu, Yulong Niu, Minhui Guan, Hao Chen, Chuan-Ying Li, Lei Wang

引用次数: 0

Abstract

Herein, we present a metal-free, concise, and efficient protocol for the intermolecular reaction of amides (lactams) with donor–acceptor α-diazo esters to afford the functionalized α-amino-α-aroylethanoates. N-Methyl-2-pyrrolidone (NMP) and N,N-dimethylformamide (DMF) are employed as both reagents and solvents, allowing for the incorporation of all units into the products. The reaction is processed by the ester group migration and compatible with a broad range of substrates up to 50 examples.

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供体-受体α-重氮酯与N，N-二甲基甲酰胺/γ-内酰胺反应生成α-氨基-α-芳酰乙醇酸酯

在本文中，我们介绍了一种无金属、简洁而高效的酰胺（内酰胺）与供体-受体 α-重氮酯分子间反应的方案，从而得到官能化的α-氨基-α-芳基乙酸酯。N 甲基-2-吡咯烷酮（NMP）和 N,N-二甲基甲酰胺（DMF）既可用作试剂，也可用作溶剂，使所有单元都能掺入产物中。该反应是通过酯基迁移进行的，可与多达 50 个实例的多种底物兼容。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.