Recent advances in enantioselective construction of C–N bonds involving radical intermediate

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-01-14 DOI:10.1039/d4qo02268h

Jiaqiong Sun, Guangfan Zheng, Ge Zhang, Yan Li, Qian Zhang

引用次数: 0

Abstract

This review offers a comprehensive overview of recent advancements in the asymmetric construction of C–N bonds involving radical intermediates. Enantioselective radical amination strategies have proven to be highly effective for synthesizing chiral amines and nitrogen-containing heterocycles. Significant progress has been made in the enantioselective installation of N–containing groups into halogenated alkanes, alkanes, olefins, and dienes with asymmetric formation of C–N bonds as the key step via diversified pathways including reductive elimination, radical-polar crossover, amino group substitution, and radical-radical cross-coupling, etc. This review highlights these recent developments and the mechanistic insights that drive these transformations.

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本综述全面概述了涉及自由基中间体的 C-N 键不对称构建的最新进展。事实证明，对映选择性自由基胺化策略在合成手性胺和含氮杂环方面非常有效。通过还原消除、自由基-极性交叉、氨基取代和自由基-自由基交叉偶联等多种途径，以不对称形成 C-N 键为关键步骤，将含 N 基团对映选择性地安装到卤代烷、烷烃、烯烃和二烯中的研究取得了重大进展。本综述重点介绍了这些最新进展以及驱动这些转化的机理见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.