Is there a relationship between lumbosacral epidural spinal injections and lumbosacral epidural lipomatosis? A retrospective study.

IF 1.5 4区医学 Q4 CLINICAL NEUROLOGY

Neurochirurgie Pub Date : 2025-01-10 DOI:10.1016/j.neuchi.2025.101636

Ali A Al-Omari, Naser Obeidat, Adham F Alnemer, Ala'M Abu Dalou

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引用次数: 0

Abstract

Background: We aim to investigate the potential association between the administration of Lumbosacral epidural steroid injections (LESIs) and the subsequent onset or progression of Lumbosacral epidural lipomatosis (LEL) in patients devoid of established risk factors for LEL.

Methods: We carried out a single-center retrospective study on patients who underwent LESI. We collected demographics including age and gender as well as clinical and radiological characteristics including the type of corticosteroids utilized, the number of LESIs administered, the use of epidural guidance during LESI procedures, and LEL grading. Any patient aged ≥18 years who underwent LESI was included. Exclusion criteria encompassed the absence of magnetic resonance imaging (MRI) data both prior to and following the intervention, presence of endocrinopathies such as Cushing's syndrome or hypothyroidism, diabetes mellitus, and hyperlipidemia.

Results: A total of 3,000 patients were initially screened, 268 patients met the inclusion criteria and were included in the analysis. Mean age was 53.63 years (±12.27), and 50% were male. The predominant treatment administered was methylprednisolone (96.4%). 86% of the patients underwent a single LESI. Fluoroscopy was the guiding modality in 250 (94%) patients. An analysis of LEL grades both before and after LESI revealed variations, with a 7.5% incidence of grade change observed. Logistic regression analysis indicated a trend between male gender and the occurrence of LEL.

Conclusions: Our study emphasizes the relationship between LESIs and the development of LEL and the progression of existing LEL. Further research should investigate this link by conducting larger controlled imaging studies.

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来源期刊

Neurochirurgie 医学-临床神经学

CiteScore

2.70

自引率

6.20%

发文量

100

审稿时长

29 days

期刊介绍： Neurochirurgie publishes articles on treatment, teaching and research, neurosurgery training and the professional aspects of our discipline, and also the history and progress of neurosurgery. It focuses on pathologies of the head, spine and central and peripheral nervous systems and their vascularization. All aspects of the specialty are dealt with: trauma, tumor, degenerative disease, infection, vascular pathology, and radiosurgery, and pediatrics. Transversal studies are also welcome: neuroanatomy, neurophysiology, neurology, neuropediatrics, psychiatry, neuropsychology, physical medicine and neurologic rehabilitation, neuro-anesthesia, neurologic intensive care, neuroradiology, functional exploration, neuropathology, neuro-ophthalmology, otoneurology, maxillofacial surgery, neuro-endocrinology and spine surgery. Technical and methodological aspects are also taken onboard: diagnostic and therapeutic techniques, methods for assessing results, epidemiology, surgical, interventional and radiological techniques, simulations and pathophysiological hypotheses, and educational tools. The editorial board may refuse submissions that fail to meet the journal''s aims and scope; such studies will not be peer-reviewed, and the editor in chief will promptly inform the corresponding author, so as not to delay submission to a more suitable journal. With a view to attracting an international audience of both readers and writers, Neurochirurgie especially welcomes articles in English, and gives priority to original studies. Other kinds of article - reviews, case reports, technical notes and meta-analyses - are equally published. Every year, a special edition is dedicated to the topic selected by the French Society of Neurosurgery for its annual report.