Recurrent Diffuse Tenosynovial Giant Cell Tumor of the Temporomandibular Joint.

IF 4.1 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2025-01-13 DOI:10.1007/s12105-024-01747-x

Leen AlQudah, Elisa Hannan, Timothy Turvey, Carlos David, Laleh Hakima

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引用次数: 0

Abstract

Purpose: Recurrent diffuse-type tenosynovial giant cell tumor: Clinical presentation, Diagnosis, and Management.

Background: Tenosynovial giant cell tumor (TGCT), is a neoplasm arising from synovial joints, bursae, or tendon sheaths. The initial clinical symptoms are vague and non-diagnostic. Patients may present with non-specific complaints such as subtle joint discomfort or pain. As the lesion progresses, the joint range of motion will become limited resulting in swelling, effusion, stiffness, and hemarthrosis. According to the World Health Organization (WHO) classification, TGCTs are divided into two main subtypes based on their growth pattern: localized or diffuse. Diffuse-type TGCTs tend to be more aggressive.

Case presentation: An 82-year-old female presented with right facial swelling and discomfort. MRI showed a large mass centered in the right temporomandibular joint (TMJ) with erosive osseous changes at the skull base. Past medical history was significant for surgical resection of TGCT of the TMJ, 5 years earlier. The patient was subsequently seen by oral and maxillofacial surgery and neurosurgery and underwent a surgical resection. Histologic examination was consistent with a recurrent diffuse-type TGCT with chondroid metaplasia.

Discussion: The role of CSF1 protein over-expression in various synovial pathologies.

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颞下颌关节复发性弥漫性腱鞘巨细胞瘤。

目的：复发性弥漫性腱鞘巨细胞瘤的临床表现、诊断和治疗。背景：滑膜巨细胞瘤（TGCT）是一种起源于滑膜关节、滑囊或肌腱鞘的肿瘤。最初的临床症状模糊，无法诊断。患者可能出现非特异性的主诉，如轻微的关节不适或疼痛。随着病变的进展，关节活动范围将受到限制，导致肿胀、积液、僵硬和关节积血。根据世界卫生组织（WHO）的分类，tgct根据其生长方式分为两种主要亚型：局部或弥漫性。弥漫性tgct更具侵袭性。病例介绍：82岁女性，右侧面部肿胀不适。MRI显示以右颞下颌关节（TMJ）为中心的大肿块伴颅底糜烂性骨改变。既往病史对手术切除5年前颞下颌关节TGCT具有重要意义。患者随后接受口腔颌面外科和神经外科治疗，并行手术切除。组织学检查符合复发性弥漫性TGCT伴软骨样化生。讨论：CSF1蛋白过表达在各种滑膜病变中的作用。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.