Implementing Mutational Epidemiology on a Global Scale: Lessons from Mutographs

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-01-13 DOI:10.1158/2159-8290.cd-24-1687

Michael R. Stratton, Laura Humphreys, Ludmil B. Alexandrov, Allan Balmain, Paul Brennan, Peter J. Campbell, David H. Phillips

引用次数: 0

Abstract

Summary: The Mutographs Cancer Grand Challenge team aimed to discover unknown causes of cancer through mutational epidemiology, an alliance of cancer epidemiology and somatic genomics. By generating whole-genome sequences from thousands of cancers and normal tissues from more than 30 countries on five continents, it discovered unsuspected mutagenic exposures affecting millions of people, raised the possibility that some carcinogens act by altering forces of selection in tissue microenvironments rather than by mutagenesis, and demonstrated changes to the direction of somatic evolution in normal cells of the human body in response to exogenous exposures and noncancer diseases. See related article by Bressan et al., p. 16 See related article by Bhattacharjee et al., p. 28 See related article by Goodwin et al., p. 34

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在全球范围内实施变异流行病学：来自变异图的教训

摘要：Mutographs 癌症大挑战团队旨在通过突变流行病学（癌症流行病学和体细胞基因组学的联盟）发现癌症的未知原因。通过生成来自五大洲 30 多个国家的数千种癌症和正常组织的全基因组序列，该研究小组发现了影响数百万人的未被察觉的诱变暴露，提出了某些致癌物质通过改变组织微环境中的选择力而非诱变作用的可能性，并证明了人体正常细胞在外源暴露和非癌症疾病作用下的体细胞进化方向的变化。见 Bressan 等人的相关文章，第 16 页见 Bhattacharjee 等人的相关文章，第 28 页见 Goodwin 等人的相关文章，第 34 页

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.