DisGeNet: a disease-centric interaction database among diseases and various associated genes.

Abstract

The pathogenesis of complex diseases is intricately linked to various genes and network medicine has enhanced understanding of diseases. However, most network-based approaches ignore interactions mediated by noncoding RNAs (ncRNAs) and most databases only focus on the association between genes and diseases. Based on the mentioned questions, we have developed DisGeNet, a database focuses not only on the disease-associated genes but also on the interactions among genes. Here, the associations between diseases and various genes, as well as the interactions among these genes are integrated into a disease-centric network. As a result, there are a total of 502 688 interactions/associations involving 6697 diseases, 5780 lncRNAs (long noncoding RNAs), 16 135 protein-coding genes, and 2610 microRNAs stored in DisGeNet. These interactions/associations can be categorized as protein-protein, lncRNA-disease, microRNA-gene, microRNA-disease, gene-disease, and microRNA-lncRNA. Furthermore, as users input name/ID of diseases/genes for search, the interactions/associations about the search content can be browsed as a list or viewed in a local network-view. Database URL: https://disgenet.cn/.