A critical analysis of the potential of iron heterobimetallic complexes in anticancer research

IF 3.8 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Inorganic Biochemistry Pub Date : 2024-12-15 DOI:10.1016/j.jinorgbio.2024.112813

Boglárka Tűz , Isabel Correia , Paulo N. Martinho

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引用次数: 0

Abstract

Due to their diverse chemical properties and high ability to interact with biological molecules and cellular processes, transition metal-based compounds have emerged as promising candidates for cancer therapy. Iron complexes are among them, however, there is a gap in the comprehensive analysis of heterometallic iron complexes in the anticancer field. This review aims to fill this gap by summarizing recent progress in the study of Fe(II) and Fe(III) heterobimetallic complexes for anticancer applications and to gather important insights and future perspectives, with special emphasis on their theranostic capabilities. Works published between 2014 and 2024 were considered in this critical survey, that covers a range of complex types, including ferrocene in bimetallic complexes with Pt, Pd, Au, Ag, Ru, Rh, Ir, Cu, Re, Sn and Co; organometallic Fe-complexes with Ru and Ag; photoactive metal complexes with Pt and Co; and magnetic resonance imaging contrast agents with Gd and Mn. Studies conducted to determine the modes of action are highlighted and suggest the involvement of the metal species in reactive oxygen species generation within cells, the impact on apoptosis and cell cycle arrest, and many others. By pursuing interdisciplinary research, innovative theranostic platforms with enhanced efficacy, specificity, and clinical relevance can be developed for cancer management.

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铁杂双金属配合物在抗癌研究中的潜力的批判性分析。

由于其不同的化学性质和与生物分子和细胞过程相互作用的高能力，过渡金属基化合物已成为癌症治疗的有希望的候选者。铁配合物就是其中之一，但在抗癌领域对异金属铁配合物的综合分析还存在空白。本文旨在通过总结铁（II）和铁（III）杂双金属配合物抗癌应用的最新研究进展来填补这一空白，并收集重要的见解和未来的展望，特别强调它们的治疗能力。在这项重要的调查中，2014年至2024年间发表的作品被考虑在内，涵盖了一系列配合物类型，包括二茂铁与Pt、Pd、Au、Ag、Ru、Rh、Ir、Cu、Re、Sn和Co的双金属配合物；有机金属铁与Ru、Ag配合物；光活性金属配合物与Pt和Co；以及Gd和Mn的磁共振成像造影剂。为确定作用模式而进行的研究被强调，并表明金属物种参与细胞内活性氧的产生，对细胞凋亡和细胞周期阻滞的影响，以及其他许多方面。通过跨学科研究，可以开发出具有更高疗效、特异性和临床相关性的创新治疗平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inorganic Biochemistry 生物-生化与分子生物学

CiteScore

7.00

自引率

10.30%

发文量

336

审稿时长

41 days

期刊介绍： The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.