Artificial intelligence-driven analysis of embryo morphokinetics in singleton, twin, and triplet pregnancies

IF 6 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Human reproduction Pub Date : 2025-01-10 DOI:10.1093/humrep/deae300

E Gómez, A Brualla, N Almunia, A Zepeda-Hernández, M Valcárcel, I Torres, I Burgos, R Jiménez, A M Villaquirán, L Parmegiani

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引用次数: 0

Abstract

In recent years, the transfer of more than one embryo has become less frequent to diminish multiple pregnancies. Even so, there is still a risk of one embryo splitting into two or even three. This report presents the case of a triamniotic monochorionic gestation in a 35-year-old woman, obtained after the transfer of a single day 5 embryo that had been previously hatched with a laser and subsequently transferred in a fresh IVF cycle. The morphokinetics of this embryo as well as another eight that produced monozygotic twins were compared with nine embryos that achieved singleton gestations. An artificial intelligence (AI) system was used to perform this analysis objectively. Embryo divisions leading to multiple gestations were slower across all analysed parameters. This was most evident in the time taken to reach the 5-cell stage (t5) (48.74 ± 3.21 versus 44.69 ± 5.61 h) and the morula stage (tM) (85.08 ± 10.00 versus 78.13 ± 5.35 h). Moreover, blastocyst diameter (161.80 ± 26.50 versus 179.10 ± 25.88 μm) and area (21 684 ± 7267.4 versus 26 516 ± 7254.8 μm2) were smaller in these embryos, but the differences did not reach statistical significance. This is the first report, to our knowledge, to use AI to analyse and compare morphokinetic parameters between singleton pregnancies and a group of embryos that produced twin and triplet pregnancies.

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人工智能驱动的单胎、双胎和三胞胎妊娠胚胎形态动力学分析

近年来，为了减少多胎妊娠，移植多于一个胚胎的情况越来越少。即便如此，一个胚胎分裂成两个甚至三个的风险仍然存在。本报告报告了一名35岁女性三羊膜单绒毛膜妊娠的病例，该病例是在移植一个5天的胚胎后获得的，该胚胎先前用激光孵化，随后在新的体外受精周期中移植。这个胚胎以及另外八个产生同卵双胞胎的胚胎的形态动力学与九个实现单胎妊娠的胚胎进行了比较。人工智能（AI）系统被用来客观地进行这一分析。在所有分析参数中，导致多胎妊娠的胚胎分裂较慢。这在5细胞期（t5）（48.74±3.21比44.69±5.61 h）和桑胚期（tM）（85.08±10.00比78.13±5.35 h）中表现得最为明显，胚泡直径（161.80±26.50比179.10±25.88 μm）和面积（21 684±7267.4比26 516±7254.8 μm2）较小，但差异无统计学意义。据我们所知，这是第一份使用人工智能分析和比较单胎妊娠和产生双胞胎和三胞胎妊娠的胚胎之间形态动力学参数的报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human reproduction 医学-妇产科学

CiteScore

10.90

自引率

6.60%

发文量

1369

审稿时长

1 months

期刊介绍： Human Reproduction features full-length, peer-reviewed papers reporting original research, concise clinical case reports, as well as opinions and debates on topical issues. Papers published cover the clinical science and medical aspects of reproductive physiology, pathology and endocrinology; including andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, early pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.