Do the ınflammatory markers have a prognostic role in an elderly patient population diagnosed with non-muscle ınvasive bladder cancer?

Cirugia y cirujanos Pub Date : 2025-01-08 DOI:10.24875/CIRU.23000278

Aykut Demirci, Tuncel Uzel, Abdullah Bolat, Halil Başar

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Abstract

Objective: To evaluate whether the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and De-Ritis ratio (DRR) are determinants of progression-free survival (PFS), recurrence-free survival (RFS) and overall survival (OS) in patients aged ≥ 70 years diagnosed with non-muscle invasive bladder cancer (NMIBC).

Method: The study included 173 elderly patients diagnosed with NMIBC between January 2015 and March 2022. The clinical and pathological data of the patients were examined. Cox regression analysis was performed.

Results: The patient's mean age was 75.6 ± 4.57 years. A statistically significant correlation was determined between higher mean NLR, PLR, and SII values and PFS (p = 0.04, p = 0.009, and p = 0.007, respectively) and OS (p = 0.001, p = 0.003, and p < 0.001, respectively). The multivariate analysis results showed that tumor size (≥ 3 cm) and PLR (> 144.6) were independent risk factors for PFS (HR: 2.09, p = 0.03; HR:3.2, p = 0.01, respectively), the presence of multiple tumors for RFS (HR: 1.73, p = 0.01), and comorbid diseases for OS (HR: 2.18, p = 0.006).

Conclusion: Inflammatory parameters were found to have no independent effects on RFS and OS in patients of advanced age with NMIBC, and only PLR could be used to predict PFS.

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ınflammatory标志物在诊断为非肌肉性ınvasive膀胱癌的老年患者群体中是否具有预后作用？

目的：评价年龄≥70岁诊断为非肌肉浸润性膀胱癌（NMIBC）患者的全身免疫炎症指数（SII）、中性粒细胞-淋巴细胞比率（NLR）、血小板-淋巴细胞比率（PLR）和De-Ritis比率（DRR）是否决定无进展生存（PFS）、无复发生存（RFS）和总生存（OS）。方法：研究纳入2015年1月至2022年3月诊断为NMIBC的173例老年患者。检查患者的临床和病理资料。进行Cox回归分析。结果：患者平均年龄75.6±4.57岁。较高的NLR、PLR和SII值与PFS（分别为p = 0.04、p = 0.009和p = 0.007）和OS（分别为p = 0.001、p = 0.003和p < 0.001）之间存在统计学意义上的相关性。多因素分析结果显示，肿瘤大小（≥3cm）和PLR（> 144.6）是PFS的独立危险因素(HR: 2.09, p = 0.03；HR:3.2, p = 0.01)， RFS患者存在多发肿瘤（HR: 1.73, p = 0.01）， OS患者存在合并症（HR: 2.18, p = 0.006）。结论：炎性参数对高龄NMIBC患者的RFS和OS无独立影响，只有PLR可用于预测PFS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cirugia y cirujanos

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