Disease Severity, Illness Perceptions, Depression and Health-Related Quality of Life in Patients With Heart Failure.

IF 3.2 3区医学 Q1 NURSING

Journal of Clinical Nursing Pub Date : 2025-01-09 DOI:10.1111/jocn.17653

Zehao Huang, Sek Ying Chair

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引用次数: 0

Abstract

Background: Disease severity negatively affects health-related quality of life (HRQOL) among people with heart failure (HF). However, the underlying mechanisms remain underexplored. Illness perceptions and depression serve as potential mediators of this relationship, but the evidence supporting this is limited.

Objective: To investigate the relationships among disease severity, illness perceptions, depression and HRQOL in people with HF, as well as to explore the mediating roles of illness perceptions and depression in the relationship between disease severity and HRQOL.

Methods: People with HF were recruited from a tertiary hospital in China between January and May 2023. All the participants were assessed for disease severity, illness perceptions, depression, HRQOL and sociodemographic and clinical characteristics. The mediation analysis was performed using PROCESS macro in SPSS. The STROBE checklist was followed.

Results: This study recruited 164 subjects. Disease severity had a significant total effect on HRQOL (β = 0.716, 95% CI: 4.475, 12.068). The results showed that illness perceptions mediated the relationship between disease severity and HRQOL (β = 0.172, 95% CI: 0.042, 0.337), accounting for 24.02% of the total effect. However, a significant mediating role of depression in this relationship was not found. Furthermore, we found that illness perceptions and depression sequentially mediated the relationship between disease severity and HRQOL (β = 0.194, 95% CI: 0.005, 0.395), which accounted for 27.09% of the total effect.

Conclusions: The effect of disease severity on HRQOL is sequentially mediated by illness perceptions and depression. Illness perceptions are important predictors of HRQOL. Targeted interventions should be employed to improve illness perceptions, thereby enhancing HRQOL among people with HF.

Relevance to clinical practice: Medical staff can carefully assess patient's illness perceptions and implement appropriate strategies to enhance these illness perceptions, thereby improving their HRQOL.

Patient or public contribution: No patient or public contribution.

查看原文本刊更多论文

心力衰竭患者的疾病严重程度、疾病认知、抑郁和健康相关生活质量

背景：疾病严重程度对心力衰竭（HF）患者的健康相关生活质量（HRQOL）有负面影响。然而，其潜在机制仍未得到充分探讨。疾病认知和抑郁是这种关系的潜在中介，但支持这一点的证据有限。目的：探讨HF患者疾病严重程度、疾病知觉、抑郁与HRQOL的关系，并探讨疾病知觉和抑郁在疾病严重程度与HRQOL关系中的中介作用。方法：于2023年1月至5月在中国某三级医院招募HF患者。对所有参与者进行疾病严重程度、疾病认知、抑郁、HRQOL以及社会人口学和临床特征的评估。采用SPSS中的PROCESS宏进行中介分析。遵循STROBE检查表。结果：本研究共招募了164名受试者。疾病严重程度对HRQOL有显著的总影响（β = 0.716, 95% CI: 4.475, 12.068）。结果显示，疾病认知介导了疾病严重程度与HRQOL的关系（β = 0.172, 95% CI: 0.042, 0.337），占总效应的24.02%。然而，没有发现抑郁在这一关系中的显著中介作用。此外，我们发现疾病认知和抑郁依次介导疾病严重程度与HRQOL之间的关系（β = 0.194, 95% CI: 0.005, 0.395），占总效应的27.09%。结论：疾病严重程度对HRQOL的影响是由疾病知觉和抑郁依次介导的。疾病认知是HRQOL的重要预测因子。应该采用有针对性的干预措施来改善疾病认知，从而提高心衰患者的HRQOL。与临床实践的相关性：医务人员可以仔细评估患者的疾病感知，并实施适当的策略来增强这些疾病感知，从而提高他们的HRQOL。患者或公众捐款：没有患者或公众捐款。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Nursing 医学-护理

CiteScore

6.40

自引率

2.40%

发文量

审稿时长

2 months

期刊介绍： The Journal of Clinical Nursing (JCN) is an international, peer reviewed, scientific journal that seeks to promote the development and exchange of knowledge that is directly relevant to all spheres of nursing practice. The primary aim is to promote a high standard of clinically related scholarship which advances and supports the practice and discipline of nursing. The Journal also aims to promote the international exchange of ideas and experience that draws from the different cultures in which practice takes place. Further, JCN seeks to enrich insight into clinical need and the implications for nursing intervention and models of service delivery. Emphasis is placed on promoting critical debate on the art and science of nursing practice. JCN is essential reading for anyone involved in nursing practice, whether clinicians, researchers, educators, managers, policy makers, or students. The development of clinical practice and the changing patterns of inter-professional working are also central to JCN''s scope of interest. Contributions are welcomed from other health professionals on issues that have a direct impact on nursing practice. We publish high quality papers from across the methodological spectrum that make an important and novel contribution to the field of clinical nursing (regardless of where care is provided), and which demonstrate clinical application and international relevance.