Correlation between obesity and Alzheimer's disease and the mechanisms.

Q3 Medicine
Tenglin Zhang, Ping Wang, Ruonan Li, Ying Wang, Shuxun Yan
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引用次数: 0

Abstract

Alzheimer's disease (AD) is a progressive central neurodegenerative disorder with an insidious onset. With global aging, the incidence and mortality of AD have been steadily increasing, yet effective treatments remain elusive. Obesity, characterized by excessive or abnormal fat accumulation, is a complex metabolic disorder and a confirmed risk factor for numerous diseases. Both obesity and AD have become major public health concerns, posing significant threats to human health and economic development. Studies have revealed a strong correlation between obesity and AD, with multiple contributing factors, including metabolic abnormalities of endocrine factors, inflammatory responses, and genetic interactions. Exploring the correlation and mechanisms between obesity and AD provides important insights and new strategies for the prevention and treatment of AD.

肥胖与阿尔茨海默病的相关性及其机制。
阿尔茨海默病(AD)是一种发病隐匿的进行性中枢神经退行性疾病。随着全球老龄化,阿尔茨海默病的发病率和死亡率稳步上升,但有效的治疗方法仍然难以捉摸。肥胖是一种复杂的代谢紊乱,是许多疾病的确定危险因素,其特征是脂肪堆积过多或异常。肥胖和AD已成为重大的公共卫生问题,对人类健康和经济发展构成重大威胁。研究表明,肥胖与AD之间存在很强的相关性,其影响因素包括内分泌因子代谢异常、炎症反应和基因相互作用等。探讨肥胖与阿尔茨海默病之间的相关性和机制,为阿尔茨海默病的防治提供了重要的见解和新的策略。
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来源期刊
中南大学学报(医学版)
中南大学学报(医学版) Medicine-Medicine (all)
CiteScore
1.00
自引率
0.00%
发文量
8237
期刊介绍: Journal of Central South University (Medical Sciences), founded in 1958, is a comprehensive academic journal of medicine and health sponsored by the Ministry of Education and Central South University. The journal has been included in many important databases and authoritative abstract journals at home and abroad, such as the American Medline, Pubmed and its Index Medicus (IM), the Netherlands Medical Abstracts (EM), the American Chemical Abstracts (CA), the WHO Western Pacific Region Medical Index (WPRIM), and the Chinese Science Citation Database (Core Database) (CSCD); it is a statistical source journal of Chinese scientific and technological papers, a Chinese core journal, and a "double-effect" journal of the Chinese Journal Matrix; it is the "2nd, 3rd, and 4th China University Excellent Science and Technology Journal", "2008 China Excellent Science and Technology Journal", "RCCSE China Authoritative Academic Journal (A+)" and Hunan Province's "Top Ten Science and Technology Journals". The purpose of the journal is to reflect the new achievements, new technologies, and new experiences in medical research, medical treatment, and teaching, report new medical trends at home and abroad, promote academic exchanges, improve academic standards, and promote scientific and technological progress.
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