Is there an association between birth characteristics and fractures in young adults? The HUNT Study, Norway.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Osteoporosis International Pub Date : 2025-03-01 Epub Date: 2025-01-08 DOI:10.1007/s00198-024-07361-5

Hilde Thomasli Holltrø, T I L Nilsen, B Schei, I Tronstad, J Horn, K Holvik, A K N Daltveit, E M Dennison, N C Harvey, A Langhammer, M Hoff

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引用次数: 0

Abstract

This population study investigated the association between birth characteristics and fracture risk in 11,099 young adults (aged 19-54 years). Our findings indicate that birth weight, gestational age, and birth weight for gestational age were not associated with fractures in the wrist, humerus, hip, and spine in this population.

Purpose: Skeletal development starts during fetal life, and it is estimated that most bone formation occurs in the 3rd trimester. This study examined the association between birth characteristics and fractures of the wrist, humerus, hip, and spine, in young adults (19-54 years).

Methods: 11.099 participants in the 3^rd survey of the HUNT Study (2006-2008) were linked with the Medical Birth Registry of Norway and hospital records. Fractures of the wrist, humerus, hip, and spine were identified using ICD9/10 codes between 1988 and 2021. Follow-up was from date of participation in HUNT until a first fracture, emigration, death, or end of study. Cox regression was used to estimate hazard ratios (HR) of fracture associated with birth characteristics (95% CI), adjusted for birth year, sex, maternal age, and maternal morbidity. In a secondary analysis, follow-up started in 1988.

Results: During a median follow-up of 14.0 years (153,657 person-years), 290 fractures occurred. Mean age at first fracture was 41.4 years (SD 7.4). Overall, there were no clear associations between birth characteristics and fractures in these data. HR for fracture was 0.43 (0.15-1.24) for those with a birth weight < 2.5 kg (reference birth weight 3.5 - 3.9 kg); 1.04 (0.74 - 1.46) for those born small for gestational age (< 10th percentile, reference 10 - 90^th percentile); and 0.63 (0.33 - 1.23) for those born preterm (reference term births). The secondary analysis from 1988, including 539 fractures, gave similar results as the main analysis.

Conclusion: Birth weight, gestational age, or birth weight for gestational age was not associated with an increased risk of fractures of the wrist, humerus, hip, and spine in young adults.

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年轻人的出生特征和骨折之间是否存在关联？HUNT研究，挪威。

这项人口研究调查了11,099名年轻成年人（19-54岁）出生特征与骨折风险之间的关系。我们的研究结果表明，在这一人群中，出生体重、胎龄和出生体重与腕部、肱骨、髋部和脊柱骨折无关。目的：骨骼发育始于胎儿时期，据估计，大多数骨骼形成发生在妊娠晚期。本研究调查了年轻成人（19-54岁）出生特征与手腕、肱骨、髋关节和脊柱骨折之间的关系。方法：在HUNT研究（2006-2008）的第三次调查中，11.099名参与者与挪威医学出生登记处和医院记录相关联。1988年至2021年间，使用ICD9/10代码识别手腕、肱骨、髋关节和脊柱骨折。随访从参与HUNT之日起至首次骨折、移民、死亡或研究结束。采用Cox回归估计骨折与出生特征相关的风险比（HR）（95% CI），校正出生年份、性别、产妇年龄和产妇发病率。在二次分析中，随访开始于1988年。结果：在中位随访14.0年（153,657人年）期间，发生290例骨折。首次骨折的平均年龄为41.4岁（SD 7.4）。总的来说，在这些数据中，出生特征和骨折之间没有明确的联系。出生体重（百分位数）的骨折风险比为0.43 (0.15-1.24)；早产儿（参考足月出生）为0.63（0.33 - 1.23）。从1988年开始的第二次分析，包括539例骨折，得出了与主要分析相似的结果。结论：出生体重、胎龄或胎龄的出生体重与年轻人手腕、肱骨、髋部和脊柱骨折的风险增加无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Osteoporosis International 医学-内分泌学与代谢

CiteScore

8.10

自引率

10.00%

发文量

224

审稿时长

3 months

期刊介绍： An international multi-disciplinary journal which is a joint initiative between the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA, Osteoporosis International provides a forum for the communication and exchange of current ideas concerning the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. It publishes: original papers - reporting progress and results in all areas of osteoporosis and its related fields; review articles - reflecting the present state of knowledge in special areas of summarizing limited themes in which discussion has led to clearly defined conclusions; educational articles - giving information on the progress of a topic of particular interest; case reports - of uncommon or interesting presentations of the condition. While focusing on clinical research, the Journal will also accept submissions on more basic aspects of research, where they are considered by the editors to be relevant to the human disease spectrum.