Efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-01-10 DOI:10.1186/s13244-024-01892-5

Mark Barwig, Michael Janisch, Johannes Gessl, Wolfgang Kübler, Christopher König, Gerold Schwantzer, Helmut Schöllnast

{"title":"Efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography.","authors":"Mark Barwig, Michael Janisch, Johannes Gessl, Wolfgang Kübler, Christopher König, Gerold Schwantzer, Helmut Schöllnast","doi":"10.1186/s13244-024-01892-5","DOIUrl":null,"url":null,"abstract":"Purpose: To assess the efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography (CCTA).Methods: The study population consisted of 37 patients (17 female; median age, 56 years; IQR, 19 years; range, 19-88 years) who underwent CCTA after intravenous injection of landiolol hydrochloride due to a heart rate > 60 bpm. Landiolol hydrochloride was administered in a stepwise manner until a heart rate of ≤ 60 bpm was achieved or a maximum dose of 60 mg was reached after six injections. Heart rates routinely displayed continuously on the CT scanner before the start of the landiolol hydrochloride injection (HRPRE), after each partial dose (HR1-6), during the CT scan (HRCT), and after the examination before moving from the CT table (HRPOST) were recorded. Furthermore, the blood pressure routinely measured before (BPPRE) and after the examination before moving from the CT table (BPPOST) was recorded.Results: A HRCT of ≤ 60 bpm was achieved in 13 patients (35%) and a HRCT ≤ 65 bpm was achieved in 25 patients (68%). The mean difference (± SD) between HRPRE and HRCT was -11 ± 9 bpm in total, -14 ± 10 bpm in patients without oral beta-blocker premedication and -6 ± 5 bpm in patients with oral Beta-blocker premedication.Conclusions: Landiolol hydrochloride enables a reduction of the heart rate in patients with and without oral beta-blocker premedication, whereby the use of serial partial doses is a simple and effective approach in clinical routine.Critical relevance statement: In cardiac CT, weight-independent, stepwise landiolol hydrochloride injection up to 40 mg reduces heart rate by -14 bpm without and -5 bpm with oral beta-blocker premedication, and achieves heart rates of ≤ 65 bpm in a significant proportion of patients.Key points: The ideal heart rate for cardiac CT is ≤ 60-65 bpm, which improves image quality and reduces radiation dose. In cardiac CT, landiolol hydrochloride intravenously reduces heart rate by -14 bpm. Heart rate of ≤ 65 bpm can be achieved in a significant proportion of patients.","PeriodicalId":13639,"journal":{"name":"Insights into Imaging","volume":"16 1","pages":"13"},"PeriodicalIF":4.1000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723858/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Insights into Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13244-024-01892-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To assess the efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography (CCTA).

Methods: The study population consisted of 37 patients (17 female; median age, 56 years; IQR, 19 years; range, 19-88 years) who underwent CCTA after intravenous injection of landiolol hydrochloride due to a heart rate > 60 bpm. Landiolol hydrochloride was administered in a stepwise manner until a heart rate of ≤ 60 bpm was achieved or a maximum dose of 60 mg was reached after six injections. Heart rates routinely displayed continuously on the CT scanner before the start of the landiolol hydrochloride injection (HR_PRE), after each partial dose (HR_1-6), during the CT scan (HR_CT), and after the examination before moving from the CT table (HR_POST) were recorded. Furthermore, the blood pressure routinely measured before (BP_PRE) and after the examination before moving from the CT table (BP_POST) was recorded.

Results: A HR_CT of ≤ 60 bpm was achieved in 13 patients (35%) and a HR_CT ≤ 65 bpm was achieved in 25 patients (68%). The mean difference (± SD) between HR_PRE and HR_CT was -11 ± 9 bpm in total, -14 ± 10 bpm in patients without oral beta-blocker premedication and -6 ± 5 bpm in patients with oral Beta-blocker premedication.

Conclusions: Landiolol hydrochloride enables a reduction of the heart rate in patients with and without oral beta-blocker premedication, whereby the use of serial partial doses is a simple and effective approach in clinical routine.

Critical relevance statement: In cardiac CT, weight-independent, stepwise landiolol hydrochloride injection up to 40 mg reduces heart rate by -14 bpm without and -5 bpm with oral beta-blocker premedication, and achieves heart rates of ≤ 65 bpm in a significant proportion of patients.

Key points: The ideal heart rate for cardiac CT is ≤ 60-65 bpm, which improves image quality and reduces radiation dose. In cardiac CT, landiolol hydrochloride intravenously reduces heart rate by -14 bpm. Heart rate of ≤ 65 bpm can be achieved in a significant proportion of patients.

查看原文本刊更多论文

大剂量注射盐酸兰地洛尔作为冠状动脉CT造影前用药的疗效观察。

目的：评价大剂量注射盐酸兰地洛尔作为冠状动脉CT血管造影（CCTA）前用药的疗效。方法：研究人群包括37例患者(女性17例；中位年龄56岁；IQR， 19岁；范围，19-88岁)，因心率bb0 60bpm接受静脉注射盐酸兰地洛尔后行CCTA。盐酸兰地洛尔以循序渐进的方式给药，直到心率≤60bpm或在6次注射后达到最大剂量60mg。记录开始盐酸兰地洛尔注射前（HRPRE）、每次部分给药后（HR1-6）、CT扫描期间（HRCT）和检查后离开CT台前（HRPOST）的常规连续显示的CT扫描仪心率。此外，记录检查前（BPPRE）和检查后离开CT台前（BPPOST）的常规血压。结果：13例（35%）患者HRCT≤60 bpm， 25例（68%）患者HRCT≤65 bpm。HRPRE与HRCT的平均差值（±SD）为-11±9 bpm，未口服-受体阻滞剂预用药组为-14±10 bpm，口服-受体阻滞剂预用药组为-6±5 bpm。结论：盐酸兰地洛尔能够降低有或没有口服β受体阻滞剂的患者的心率，因此在临床常规中使用连续部分剂量是一种简单有效的方法。关键相关性声明：在心脏CT中，体重无关的，逐步注射盐酸兰地洛尔40mg可使心率降低-14 bpm，而口服β受体阻滞剂可使心率降低-5 bpm，并使显著比例的患者心率达到≤65 bpm。重点：心脏CT的理想心率≤60- 65bpm，提高了图像质量，降低了辐射剂量。在心脏CT上，静脉注射盐酸兰地洛尔可使心率降低- 14bpm。很大一部分患者的心率可以达到≤65 bpm。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.